Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 910721..911378 Replicon chromosome
Accession NZ_CP065167
Organism Klebsiella pneumoniae strain KPN114

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag I3U24_RS04565 Protein ID WP_002916310.1
Coordinates 910968..911378 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag I3U24_RS04560 Protein ID WP_002916312.1
Coordinates 910721..910987 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I3U24_RS04535 905877..907310 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
I3U24_RS04540 907429..908157 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
I3U24_RS04545 908207..908518 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
I3U24_RS04550 908682..909341 + 660 WP_002916317.1 hemolysin III family protein -
I3U24_RS04555 909492..910475 - 984 WP_004185555.1 tRNA-modifying protein YgfZ -
I3U24_RS04560 910721..910987 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
I3U24_RS04565 910968..911378 + 411 WP_002916310.1 protein YgfX Toxin
I3U24_RS04570 911385..911906 - 522 WP_004144730.1 flavodoxin FldB -
I3U24_RS04575 912007..912903 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
I3U24_RS04580 912926..913639 + 714 WP_004185548.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
I3U24_RS04585 913645..915378 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T182207 WP_002916310.1 NZ_CP065167:910968-911378 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T182207 NZ_CP086340:3757272-3757550 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT182207 WP_002916312.1 NZ_CP065167:910721-910987 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT182207 NZ_CP086340:3757009-3757269 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References