Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 67021..67693 Replicon chromosome
Accession NZ_CP065152
Organism Escherichia coli O150:H6 strain FEX669

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag H7994_RS00445 Protein ID WP_097520786.1
Coordinates 67373..67693 (+) Length 107 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag H7994_RS00440 Protein ID WP_097520784.1
Coordinates 67021..67341 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H7994_RS00410 62106..62384 - 279 WP_097520776.1 helix-turn-helix transcriptional regulator -
H7994_RS00415 62650..64062 - 1413 WP_196316073.1 DUF3987 domain-containing protein -
H7994_RS00420 64382..65053 - 672 WP_097520780.1 inovirus Gp2 family protein -
H7994_RS00425 65450..66268 + 819 WP_097520782.1 DUF945 domain-containing protein -
H7994_RS00430 66301..66774 + 474 WP_021555650.1 DNA repair protein RadC -
H7994_RS00435 66782..67003 + 222 WP_047955988.1 DUF987 family protein -
H7994_RS00440 67021..67341 + 321 WP_097520784.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
H7994_RS00445 67373..67693 + 321 WP_097520786.1 TA system toxin CbtA family protein Toxin
H7994_RS00450 68532..69509 + 978 WP_016233480.1 carbon starvation induced protein CsiD -
H7994_RS00455 69529..70797 + 1269 WP_001539394.1 L-2-hydroxyglutarate oxidase -
H7994_RS00460 70820..70957 + 138 WP_196316075.1 hypothetical protein -
H7994_RS00465 70980..72428 + 1449 WP_024705047.1 NADP-dependent succinate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(8-105)

Antitoxin

Antitoxin CbeA

(4-102)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12008.73 Da        Isoelectric Point: 6.0623

>T182137 WP_097520786.1 NZ_CP065152:67373-67693 [Escherichia coli O150:H6]
MHILSVPTTVPVSSRLSPVQVWQQLLTYLLEQHYGLTLNDTPFHDDAAIKEHIEAGITLADAVNFLVEKYELVRIDRKGF
SWQDQTPFLSATDILRARRATGIMST

Download         Length: 321 bp

>T182137 NZ_CP086334:c3159235-3158924 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12054.73 Da        Isoelectric Point: 6.7439

>AT182137 WP_097520784.1 NZ_CP065152:67021-67341 [Escherichia coli O150:H6]
MKNSWGLRRDMTPCFGARLVQEGRRLHFLADRADISGAFNEEEALRLDQAFPLVMKQLELMLTTGELNPRHQHCVTLHHN
GLTCEADTLGSHGYVYIVIYPQTSSQ

Download         Length: 321 bp

>AT182137 NZ_CP086334:c3158923-3158633 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACACCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGAAC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACTGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAGGCACTTAACCGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References