Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-RelB
Location 1484231..1484790 Replicon chromosome
Accession NZ_CP065151
Organism Vibrio kanaloae strain R17

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag BTD91_RS20740 Protein ID WP_077681805.1
Coordinates 1484512..1484790 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F9RXS2
Locus tag BTD91_RS20735 Protein ID WP_006710667.1
Coordinates 1484231..1484515 (+) Length 95 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
BTD91_RS20700 1479289..1479531 - 243 WP_077681789.1 helix-turn-helix domain-containing protein -
BTD91_RS20705 1479620..1480573 - 954 WP_077681788.1 hypothetical protein -
BTD91_RS20710 1480650..1481828 - 1179 WP_077681787.1 site-specific integrase -
BTD91_RS20715 1481995..1482111 - 117 WP_077681793.1 DUF3265 domain-containing protein -
BTD91_RS20720 1482102..1482851 - 750 WP_077681864.1 metallophosphatase family protein -
BTD91_RS20725 1482881..1482973 - 93 WP_077681807.1 DUF3265 domain-containing protein -
BTD91_RS20730 1482988..1484031 - 1044 WP_077681806.1 hypothetical protein -
BTD91_RS20735 1484231..1484515 + 285 WP_006710667.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
BTD91_RS20740 1484512..1484790 + 279 WP_077681805.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
BTD91_RS20745 1484927..1485700 - 774 WP_077681804.1 aminoglycoside phosphotransferase family protein -
BTD91_RS20750 1485837..1486259 - 423 WP_077681803.1 hypothetical protein -
BTD91_RS20755 1486406..1486993 - 588 WP_077681802.1 hypothetical protein -
BTD91_RS20760 1487098..1487775 - 678 WP_077681800.1 response regulator -
BTD91_RS20765 1487910..1488407 - 498 WP_017057199.1 hypothetical protein -
BTD91_RS20770 1488343..1488579 - 237 WP_077681798.1 DUF3265 domain-containing protein -
BTD91_RS20775 1488951..1489094 - 144 WP_077681796.1 DUF3265 domain-containing protein -
BTD91_RS20780 1489057..1489479 - 423 WP_017054818.1 GNAT family N-acetyltransferase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1482988..1505530 22542
- inside Integron - katA 1346..1507736 1506390


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 93 a.a.        Molecular weight: 10807.50 Da        Isoelectric Point: 4.5370

>T182135 WP_077681805.1 NZ_CP065151:1484512-1484790 [Vibrio kanaloae]
MILWEEESLNDREKIFEFLYDFNPDAADKTDEIIEAKVENLLEQPLMGVQRDGIRGRLLIIPKISMIVSYWVDGSAIRVM
RVLHQKQKFPTD

Download         Length: 279 bp

>T182135 NZ_CP086334:c2781430-2781080 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGGTGAGGTGGTGGAAGAGGC
GTTATTACGTTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10857.17 Da        Isoelectric Point: 8.0515

>AT182135 WP_006710667.1 NZ_CP065151:1484231-1484515 [Vibrio kanaloae]
MDTRIQFRVDDEIKRLAQQMAESQGRTLSDACRELTEQMAEQQRKALSHDAWLTEQVNLAFEKFDSGKASFVDHDSAKAR
MAERKAKIRSRGQQ

Download         Length: 285 bp

>AT182135 NZ_CP086334:c2781675-2781424 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTTCAGGTATGGTCATTCCTAATGTTGTGATGAAAGAACTTAACTTACG
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCACGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A109D557

References