Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3574570..3575269 Replicon chromosome
Accession NZ_CP065148
Organism Proteus mirabilis strain PmBJ012

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag I0U42_RS16285 Protein ID WP_004249093.1
Coordinates 3574570..3574956 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag I0U42_RS16290 Protein ID WP_004246828.1
Coordinates 3574949..3575269 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0U42_RS16270 3570589..3571170 - 582 WP_049198882.1 DNA-3-methyladenine glycosylase I -
I0U42_RS16275 3571421..3572326 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
I0U42_RS16280 3572336..3574408 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
I0U42_RS16285 3574570..3574956 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I0U42_RS16290 3574949..3575269 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
I0U42_RS16295 3575318..3575752 - 435 WP_004246827.1 hypothetical protein -
I0U42_RS16300 3575745..3576629 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
I0U42_RS16305 3576846..3578132 - 1287 WP_017628657.1 DUF3748 domain-containing protein -
I0U42_RS16310 3578269..3578886 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
I0U42_RS16315 3579188..3579811 + 624 WP_004246821.1 guanylate kinase -
I0U42_RS16320 3579866..3580141 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T182131 WP_004249093.1 NZ_CP065148:3574570-3574956 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T182131 NZ_CP086334:c2230170-2229250 [Escherichia coli]
ATGGATCTGCGTGATAGCTATGCCCGGCAGGTCAAACTGTTGATGGCCGCTCTGCCGTATGTGGCGAAGGAGTCCTGTTT
CGCGTTGAAAGGCGGCACCGCAATCAATTTGTTTGTGCAGGATTTTCCCCGTCTGTCGGTGGATATTGATCTGGCGTATA
AGAGCTTTGCGGATCGCGATACTGATCTGGCGGCTATCAACGACGCTTTGAAGAGGATTACTGCATCGCTGAACGGCAGA
CCGGGGATCACCGCGATTCGGCAGGAAAATAAAGCGGATGAAAAGCGCATCATTGTGAATACCGCTGATGCAAAGATTAA
GATCGAGGTTAGCCCGGTCTGGCGCGGGCTGTTGTTGCCTCCGGCAGAAATGCCTGTGTGCGAACGTGTGGAAATGGAGT
ATGGCTTCACCACCATGAGTGTCGTCTCGCTGGCGGATCTTTATGGCGGTAAAATCTGCGCAGCGCTTGATCGTCAGCAC
CCGCGCGATCTGTTTGATGTGCTGAATATGCTGGAGAAACCGGGACTGATGCGGGAGATCTTTGACGGTTTTCTTTGTTA
TCTGGCAGGCCATCCCCGCCCCATTGCCGAGTTGCTGGCCCCAAACTGGGATACAGAGCGGATCACGACGCTGTATGCTC
AGGAATTTTCGGGGATGACTCAGCAGGAAACGTCGCTGGAATCGCTGCTGTCAGTAACGACTTTGCTGCCGCAGGCGTTG
AAGTCACATCTTACGGATCTGGATCGCGAGTTCTTGCTCAGTTTTAAGCAAAACAGCCCTGACTGGTCGCGGTATCGCTA
TCCTGAAATTCAGCATCTTCCGGCTATTCGCTGGAAGCAACGTAATCTGGCGGTGCTGAAAGATAAAAATCCGGCGAAGT
ATGTGGCGGCGGTGAATAAGCTAGAGAGGGTGCTGGCGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT182131 WP_004246828.1 NZ_CP065148:3574949-3575269 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT182131 NZ_CP086334:c2230939-2230157 [Escherichia coli]
TTGCCAAACTATCTAAACTGGCTGATGCAGCACACGCTACCCGGCCAGGTGCTGCTCCAGTCATGGCTTACCCGCAACGG
CATAGATCGTAAGCTCTCTTATCTCTATGTGAAGAATGGCTGGCTCAGGCGGATCGCTCACGGCGTATACTGCCGGACGG
GTCGTGAACCGGATTGGGTGGATGCGGTTTACTGCCTGCAATCGCAGTGGGAAAAGCCTGTTCGGGTGGCGGGGCTAACC
AGCCTTGCGCTTCAGGGTCATGCGCACTATACCGAACAGGGTAAGCCGCAGGTCTGGCTCGCGCTTCCGGCTTACGTCAA
ACTGCCGGGATGGTTTTCTGCCTTTGAACAATCCGCAACATTTGTCACGCTGTATACGTCAGGCCTTACCGCTGATGTAA
CGCCATTTACTACGGAACTGAAAATTGGTGACCGGCAGTTAGCGGGCAGTGTCCCGGAACTGGTCGCGTATGAGATCGCT
TGTGGCGTTCCTTCGTTGATCTCGTTCGAACATGCCGATGCTCTGTTTCAGGGGATGAATCTTCTCAGCCCGCGTAAATT
GCAGGCGTTACTCTGCGCCAGTCATTCGGTTAAAACCAACCGGGTGATGCTTTACCTTGCCCGGCGTAATGGACACCCTT
ATTTTCAGTTTATTGATCAAAGCGGTATAGAAACAGGTACGGGAAAGCGGCAAATCATACCCGGCGGCTGGCTGGAGCCG
GATTATCAAATTACTGTTCCACGCGCATTTAAACCGGAAGGAGTCGAAGATGGATCTGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References