Detailed information of TA system TA182128

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 106870..108468
• Replicon: chromosome
• Accession: NZ_CP065148
• Organism: Proteus mirabilis strain PmBJ012

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I0U42_RS00510
• Protein ID: WP_195858359.1
• Coordinates: 106870..108213 (-)
• Length: 448 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: I0U42_RS00515
• Protein ID: WP_041701484.1
• Coordinates: 108217..108468 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U42_RS00490	102487..103671	+	1185	WP_004246423.1	multidrug efflux MFS transporter EmrD	-
I0U42_RS00495	103781..105313	-	1533	WP_004246422.1	glycerol kinase GlpK	-
I0U42_RS00500	105356..106171	-	816	WP_004246421.1	aquaporin	-
I0U42_RS00505	106468..106710	+	243	WP_012368679.1	cell division protein ZapB	-
I0U42_RS00510	106870..108213	-	1344	WP_195858359.1	type II toxin-antitoxin system HipA family toxin	Toxin
I0U42_RS00515	108217..108468	-	252	WP_041701484.1	helix-turn-helix domain-containing protein	Antitoxin
I0U42_RS00520	109044..109562	-	519	WP_004246419.1	ribonuclease E activity regulator RraA	-
I0U42_RS00525	109671..110588	-	918	WP_049199260.1	1,4-dihydroxy-2-naphthoate polyprenyltransferase	-
I0U42_RS00530	110687..112027	-	1341	WP_004246417.1	HslU--HslV peptidase ATPase subunit	-
I0U42_RS00535	112040..112570	-	531	WP_004246416.1	ATP-dependent protease subunit HslV	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (150-399)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-63)

Sequences

Toxin

Protein

• Length: 448 a.a.
• Molecular weight: 49714.15 Da
• Isoelectric Point: 5.3203

>T182128 WP_195858359.1 NZ_CP065148:c108213-106870 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRLSSGTSSQNMMVSN

Nucleotide

• Length: 1344 bp

>T182128 NZ_CP086334:c1465220-1464846 [Escherichia coli]
ATGAAAACATTATCCGACACACATGTACGGGAGGTATCTCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAT
CCGACTGCTGGACCAGCATTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTTAATTTTCTCGTGGAAAAATATGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACCTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9390.83 Da
• Isoelectric Point: 9.8955

>AT182128 WP_041701484.1 NZ_CP065148:c108468-108217 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Nucleotide

• Length: 252 bp

>AT182128 NZ_CP086334:c1465641-1465267 [Escherichia coli]
GTGTCAGACAAACTCTCCGGGATAACTCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTTCCCTGCACAGTGAG
GCCCTGTTTTGGCGCTCGTCTGGTGCAAGAGGGTAACCGCCTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGCT
TCAGCGACGCAGATGCATACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGATATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCAGCACCCGCAACCACCTCATAA