Detailed information of TA system TA182126

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3866138..3867709
• Replicon: chromosome
• Accession: NZ_CP065147
• Organism: Proteus mirabilis strain PmBJ015

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I0U46_RS17590
• Protein ID: WP_124740921.1
• Coordinates: 3866138..3867451 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: I0U46_RS17595
• Protein ID: WP_004249771.1
• Coordinates: 3867452..3867709 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U46_RS17570	3861307..3862110	+	804	WP_004249775.1	energy transducer TonB	-
I0U46_RS17575	3862164..3864125	-	1962	WP_036971861.1	hypothetical protein	-
I0U46_RS17580	3864157..3865086	-	930	WP_004246518.1	metallophosphoesterase	-
I0U46_RS17585	3865271..3865735	-	465	WP_124740922.1	DUF1097 domain-containing protein	-
I0U46_RS17590	3866138..3867451	-	1314	WP_124740921.1	type II toxin-antitoxin system HipA family toxin	Toxin
I0U46_RS17595	3867452..3867709	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
I0U46_RS17600	3867985..3868614	-	630	WP_001145449.1	hypothetical protein	-
I0U46_RS17605	3868757..3868822	+	66	Protein_3407	EAL domain-containing protein	-
I0U46_RS17610	3868962..3869726	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
I0U46_RS17615	3869844..3869912	-	69	Protein_3409	EAL domain-containing protein	-
I0U46_RS17620	3870233..3870733	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
I0U46_RS17625	3870861..3871700	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
I0U46_RS17630	3871694..3872041	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49657.79 Da
• Isoelectric Point: 6.8241

>T182126 WP_124740921.1 NZ_CP065147:c3867451-3866138 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIKQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T182126 NZ_CP086334:1083668-1083775 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT182126 WP_004249771.1 NZ_CP065147:c3867709-3867452 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT182126 NZ_CP086334:c1083615-1083554 [Escherichia coli]
TGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: B4F0T9