Detailed information of TA system TA182120

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3864739..3866310
• Replicon: chromosome
• Accession: NZ_CP065146
• Organism: Proteus mirabilis strain PmBJ020

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I0U47_RS17565
• Protein ID: WP_124740921.1
• Coordinates: 3864739..3866052 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: I0U47_RS17570
• Protein ID: WP_004249771.1
• Coordinates: 3866053..3866310 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U47_RS17545	3859908..3860711	+	804	WP_004249775.1	energy transducer TonB	-
I0U47_RS17550	3860765..3862726	-	1962	WP_036971861.1	hypothetical protein	-
I0U47_RS17555	3862758..3863687	-	930	WP_004246518.1	metallophosphoesterase	-
I0U47_RS17560	3863872..3864336	-	465	WP_124740922.1	DUF1097 domain-containing protein	-
I0U47_RS17565	3864739..3866052	-	1314	WP_124740921.1	type II toxin-antitoxin system HipA family toxin	Toxin
I0U47_RS17570	3866053..3866310	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
I0U47_RS17575	3866586..3867215	-	630	WP_001145449.1	hypothetical protein	-
I0U47_RS17580	3867358..3867423	+	66	Protein_3402	EAL domain-containing protein	-
I0U47_RS17585	3867563..3868327	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
I0U47_RS17590	3868445..3868513	-	69	Protein_3404	EAL domain-containing protein	-
I0U47_RS17595	3868834..3869334	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
I0U47_RS17600	3869462..3870301	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
I0U47_RS17605	3870295..3870642	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49657.79 Da
• Isoelectric Point: 6.8241

>T182120 WP_124740921.1 NZ_CP065146:c3866052-3864739 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIKQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T182120 NZ_CP086334:107274-107525 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACAGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT182120 WP_004249771.1 NZ_CP065146:c3866310-3866053 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT182120 NZ_CP086334:107522-107776 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9