Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3573174..3573873 Replicon chromosome
Accession NZ_CP065146
Organism Proteus mirabilis strain PmBJ020

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag I0U47_RS16270 Protein ID WP_004249093.1
Coordinates 3573174..3573560 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag I0U47_RS16275 Protein ID WP_004246828.1
Coordinates 3573553..3573873 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0U47_RS16255 3569193..3569774 - 582 WP_049198882.1 DNA-3-methyladenine glycosylase I -
I0U47_RS16260 3570025..3570930 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
I0U47_RS16265 3570940..3573012 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
I0U47_RS16270 3573174..3573560 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I0U47_RS16275 3573553..3573873 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
I0U47_RS16280 3573922..3574356 - 435 WP_004246827.1 hypothetical protein -
I0U47_RS16285 3574349..3575233 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
I0U47_RS16290 3575450..3576736 - 1287 WP_017628657.1 DUF3748 domain-containing protein -
I0U47_RS16295 3576873..3577490 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
I0U47_RS16300 3577792..3578415 + 624 WP_004246821.1 guanylate kinase -
I0U47_RS16305 3578470..3578745 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T182119 WP_004249093.1 NZ_CP065146:3573174-3573560 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T182119 NZ_CP086333:c4554079-4553927 [Xanthomonas translucens pv. arrhenatheri]
ATGAAGCGACTGTTCACCTTGATGATGCTGACCCTGTTCTGTGCAGGCATGCTGACTGGCTGCAACACCATGGCCGGTGC
TGGCAAGGATATGCAGAAGGCCGGCGATAAGGTGGAAAACAAGGCCGACGACTGCAAAGACGGCAAGTGCTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT182119 WP_004246828.1 NZ_CP065146:3573553-3573873 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT182119 NZ_CP086333:c4553828-4553694 [Xanthomonas translucens pv. arrhenatheri]
ATGAAGCGTACTTTCGCGTGGATGCTGCTGGCGATGTTTTCGGTGGGCCTGCTGTCGGGCTGCAACACGGTTGCCGGTGC
CGGCAAGGACGTGAAGAGCGCCGGCGAGAAGGTCGAAGACGCCGCCAAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References