Detailed information of TA system TA182110

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1589638..1591209
• Replicon: chromosome
• Accession: NZ_CP065145
• Organism: Proteus mirabilis strain PmBJ023

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I0U43_RS06980
• Protein ID: WP_124740921.1
• Coordinates: 1589638..1590951 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: I0U43_RS06985
• Protein ID: WP_004249771.1
• Coordinates: 1590952..1591209 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U43_RS06960	1584807..1585610	+	804	WP_004249775.1	energy transducer TonB	-
I0U43_RS06965	1585664..1587625	-	1962	WP_036971861.1	hypothetical protein	-
I0U43_RS06970	1587657..1588586	-	930	WP_004246518.1	metallophosphoesterase	-
I0U43_RS06975	1588771..1589235	-	465	WP_124740922.1	DUF1097 domain-containing protein	-
I0U43_RS06980	1589638..1590951	-	1314	WP_124740921.1	type II toxin-antitoxin system HipA family toxin	Toxin
I0U43_RS06985	1590952..1591209	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
I0U43_RS06990	1591485..1592114	-	630	WP_001145449.1	hypothetical protein	-
I0U43_RS06995	1592257..1592322	+	66	Protein_1359	EAL domain-containing protein	-
I0U43_RS07000	1592462..1593226	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
I0U43_RS07005	1593344..1593412	-	69	Protein_1361	EAL domain-containing protein	-
I0U43_RS07010	1593733..1594233	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
I0U43_RS07015	1594361..1595200	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
I0U43_RS07020	1595194..1595541	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49657.79 Da
• Isoelectric Point: 6.8241

>T182110 WP_124740921.1 NZ_CP065145:c1590951-1589638 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIKQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T182110 NZ_CP086332:c3689496-3689218 [Xanthomonas translucens pv. phleipratensis]
GTGATTAAAAATTTTGCAGATAAGAACACTGAGAAGATCGCCCAAGGCAAACGGGTCCGCGCTTGGGCGAGTATCGAGAG
ACAGATTCAACGAAAACTGGAGTACCTGAAAGCTGCTGTAGAACTTGGTGACTTGCGAGCACCGCCCGGCAACATGCTGG
AACAGCTGAAGGGCGACCGGCAGGGGCAATACAGCATCAGGATCAACGACCAGTATCGAATATGTTTCAGGTGGGAAGGT
GGTGATGCTTACGATGTAGAGGTCACCGATTACCACTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT182110 WP_004249771.1 NZ_CP065145:c1591209-1590952 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT182110 NZ_CP086332:c3689101-3688784 [Xanthomonas translucens pv. phleipratensis]
ATGAACGCCACCGCGAACAAAAAGGTCGCCAACGCGCTCCCTCCGGTCCATCCTGGTGAAATACTGGCCGAGGACTTCCT
GTCACCACTAGGCATGTCCGCCCGCAGTCTAGCTGCGGCGATCGACGTAACCCCCGCCCGCGTGTCCGACATCATCGCCG
GCCGTCGTGGCATCACCGCCGACACTGCACTGCGCCTTGGCCGCTACTTCGGCACCACGGCACAGCTTTGGCTGAACCTG
CAGACGAATTTTGACCTGGAAACTGCTAGCCGTGAGCTAGCCGATTCCATCACACATATCCGCCCCCGGGCGGCTTGA

Structures

Antitoxin

• AlphaFold DB: B4F0T9