Detailed information of TA system TA182108

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 3866145..3867716
• Replicon: chromosome
• Accession: NZ_CP065144
• Organism: Proteus mirabilis strain PmBJ024

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: I0U44_RS17585
• Protein ID: WP_124740921.1
• Coordinates: 3866145..3867458 (-)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: B4F0T9
• Locus tag: I0U44_RS17590
• Protein ID: WP_004249771.1
• Coordinates: 3867459..3867716 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U44_RS17565	3861314..3862117	+	804	WP_004249775.1	energy transducer TonB	-
I0U44_RS17570	3862171..3864132	-	1962	WP_036971861.1	hypothetical protein	-
I0U44_RS17575	3864164..3865093	-	930	WP_004246518.1	metallophosphoesterase	-
I0U44_RS17580	3865278..3865742	-	465	WP_124740922.1	DUF1097 domain-containing protein	-
I0U44_RS17585	3866145..3867458	-	1314	WP_124740921.1	type II toxin-antitoxin system HipA family toxin	Toxin
I0U44_RS17590	3867459..3867716	-	258	WP_004249771.1	helix-turn-helix domain-containing protein	Antitoxin
I0U44_RS17595	3867992..3868621	-	630	WP_001145449.1	hypothetical protein	-
I0U44_RS17600	3868764..3868829	+	66	Protein_3406	EAL domain-containing protein	-
I0U44_RS17605	3868969..3869733	-	765	WP_001389365.1	IS6-like element IS6100 family transposase	-
I0U44_RS17610	3869851..3869919	-	69	Protein_3408	EAL domain-containing protein	-
I0U44_RS17615	3870240..3870740	-	501	WP_000376623.1	GNAT family N-acetyltransferase	-
I0U44_RS17620	3870868..3871707	-	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
I0U44_RS17625	3871701..3872048	-	348	WP_000679427.1	quaternary ammonium compound efflux SMR transporter QacE delta 1	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (13-65)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49657.79 Da
• Isoelectric Point: 6.8241

>T182108 WP_124740921.1 NZ_CP065144:c3867458-3866145 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDTELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDAKLAMGLKASRGKKYAIKQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Nucleotide

• Length: 1314 bp

>T182108 NZ_CP086332:3687736-3687987 [Xanthomonas translucens pv. phleipratensis]
ATGGACACCATCACCTATAGCGCTGCACGCGCCGCCCTCGCGGACACCATGGAGCGTGTCGTCAACAATCACGAGCCGGT
GATCATCACCCGCAGCCGCGAGCAATCCGTGGTCATGCTGTCGCTTGAGGACTACAAGGCGATGGAGGAAACCGCCTACC
TGCTCCGCAGTCCGAAGAGCGCGCAGCGCCTGCTGGAATCCATCGCCCAGCTCGAGGCCGGTCGCGGCAAGGCACGGGAT
CTGGCCGAGTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9878.43 Da
• Isoelectric Point: 10.0139

>AT182108 WP_004249771.1 NZ_CP065144:c3867716-3867459 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Nucleotide

• Length: 258 bp

>AT182108 NZ_CP086332:3687984-3688241 [Xanthomonas translucens pv. phleipratensis]
GTGACGGTTCAGTTCTCGGACAATGCCTGGGAGGACGACCTCTACTGGCAGCAGACCGACAAGAAGATGCTCAAACGCAT
CAACGACCTGATCAAAGCCATTCAACGCGATCCCTTCCAAGGCGTCGGCAAGCCAGAACCGCTACGCCATGCCTTGGCCG
GCTATTGGTCGCGGCGCATCAACGACGAACACCGCATCGTGTACAAGGTCGAGGCGGGCGTCCTGCTGATCGCGCAGGTG
CGCTACCACTACGTGTAG

Structures

Antitoxin

• AlphaFold DB: B4F0T9