Detailed information of TA system TA182107

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-MqsA
• Location: 3574577..3575276
• Replicon: chromosome
• Accession: NZ_CP065144
• Organism: Proteus mirabilis strain PmBJ024

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B4EZ96
• Locus tag: I0U44_RS16285
• Protein ID: WP_004249093.1
• Coordinates: 3574577..3574963 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4EZ97
• Locus tag: I0U44_RS16290
• Protein ID: WP_004246828.1
• Coordinates: 3574956..3575276 (+)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I0U44_RS16270	3570596..3571177	-	582	WP_049198882.1	DNA-3-methyladenine glycosylase I	-
I0U44_RS16275	3571428..3572333	+	906	WP_004246832.1	glycine--tRNA ligase subunit alpha	-
I0U44_RS16280	3572343..3574415	+	2073	WP_004246830.1	glycine--tRNA ligase subunit beta	-
I0U44_RS16285	3574577..3574963	+	387	WP_004249093.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I0U44_RS16290	3574956..3575276	+	321	WP_004246828.1	helix-turn-helix domain-containing protein	Antitoxin
I0U44_RS16295	3575325..3575759	-	435	WP_004246827.1	hypothetical protein	-
I0U44_RS16300	3575752..3576636	-	885	WP_012368526.1	endonuclease/exonuclease/phosphatase family protein	-
I0U44_RS16305	3576853..3578139	-	1287	WP_017628657.1	DUF3748 domain-containing protein	-
I0U44_RS16310	3578276..3578893	+	618	WP_004246822.1	trimeric intracellular cation channel family protein	-
I0U44_RS16315	3579195..3579818	+	624	WP_004246821.1	guanylate kinase	-
I0U44_RS16320	3579873..3580148	+	276	WP_004246820.1	DNA-directed RNA polymerase subunit omega	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-2 (1-125)

Antitoxin

• Cro/C1-type helix-turn-helix domain (53-95)

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14294.64 Da
• Isoelectric Point: 10.0642

>T182107 WP_004249093.1 NZ_CP065144:3574577-3574963 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Nucleotide

• Length: 387 bp

>T182107 NZ_CP086332:734482-734958 [Xanthomonas translucens pv. phleipratensis]
TTGTCGCTCACTGTTCCCGGCCCGCTCAACGACGTGCATCGGCTGGACGACTTCCAGTGCAGTGCACCGGAACTGACAAG
ATGGCTGCTGGAACGAGCGCACCAGAATCAGCTATCCGGCGCATCTAGGTGCTTCGTCGTCTGCGACGGACAGCAGCGCG
TTGTGGGCTACTACGCACTGGCGGCCGGTGTGGTGGCGCATGAAGACGCGCCTGGCCGCATCCGTCGCAACATGCCCAAT
CCCGTTCCGGTGATCGTCCTGGGGCGTCTGGCGGTGCACGTCGACTGGGCCGGCCAGGGCGTCGGCAGGGGATTGCTCAA
GGACGCCGTACAACGAACGTTGCAGGTCTGCGAGCAGGTGGGCGCCCGTGCGCTGCTGTGTCACGCCATCGATGAAGCAG
CGAAGGCGTTCTATCTCAAACACGGCTTCATCGCCTCGCCCATCCACGATAGGACGGTGATGTTGCCGCTTAGGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 12126.21 Da
• Isoelectric Point: 10.4411

>AT182107 WP_004246828.1 NZ_CP065144:3574956-3575276 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Nucleotide

• Length: 321 bp

>AT182107 NZ_CP086332:734207-734479 [Xanthomonas translucens pv. phleipratensis]
ATGAGCGCCGTCACCAGCAAAGTCATCAATTTTCGGGCGCCTGCTGCCAAACAGGCGCTGATCGACCACGCCGTGGAAGT
CAGCGGCATGAACCGCACAGAGTTCATCCTGGACGCCGTGTGCGAGAAGGCGCGCGAGGTGCTGGCCGACCAGACCCGAT
TCGCCCTGAGCCCGCAGCAGCTGCAGCGCTTCAATGCACTACTCGATGCGCCTCTGGAGAGTAATGCAGCGATCCGTCGC
CTGTTGAGCACGCCGGCGCCTTGGGAACACTGA

Structures

Toxin

• AlphaFold DB: B4EZ96

Antitoxin

• AlphaFold DB: B4EZ97