182107

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 3574577..3575276 Replicon chromosome
Accession NZ_CP065144
Organism Proteus mirabilis strain PmBJ024

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag I0U44_RS16285 Protein ID WP_004249093.1
Coordinates 3574577..3574963 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag I0U44_RS16290 Protein ID WP_004246828.1
Coordinates 3574956..3575276 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0U44_RS16270 3570596..3571177 - 582 WP_049198882.1 DNA-3-methyladenine glycosylase I -
I0U44_RS16275 3571428..3572333 + 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
I0U44_RS16280 3572343..3574415 + 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
I0U44_RS16285 3574577..3574963 + 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I0U44_RS16290 3574956..3575276 + 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
I0U44_RS16295 3575325..3575759 - 435 WP_004246827.1 hypothetical protein -
I0U44_RS16300 3575752..3576636 - 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
I0U44_RS16305 3576853..3578139 - 1287 WP_017628657.1 DUF3748 domain-containing protein -
I0U44_RS16310 3578276..3578893 + 618 WP_004246822.1 trimeric intracellular cation channel family protein -
I0U44_RS16315 3579195..3579818 + 624 WP_004246821.1 guanylate kinase -
I0U44_RS16320 3579873..3580148 + 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T182107 WP_004249093.1 NZ_CP065144:3574577-3574963 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T182107 NZ_CP086332:734482-734958 [Xanthomonas translucens pv. phleipratensis]
TTGTCGCTCACTGTTCCCGGCCCGCTCAACGACGTGCATCGGCTGGACGACTTCCAGTGCAGTGCACCGGAACTGACAAG
ATGGCTGCTGGAACGAGCGCACCAGAATCAGCTATCCGGCGCATCTAGGTGCTTCGTCGTCTGCGACGGACAGCAGCGCG
TTGTGGGCTACTACGCACTGGCGGCCGGTGTGGTGGCGCATGAAGACGCGCCTGGCCGCATCCGTCGCAACATGCCCAAT
CCCGTTCCGGTGATCGTCCTGGGGCGTCTGGCGGTGCACGTCGACTGGGCCGGCCAGGGCGTCGGCAGGGGATTGCTCAA
GGACGCCGTACAACGAACGTTGCAGGTCTGCGAGCAGGTGGGCGCCCGTGCGCTGCTGTGTCACGCCATCGATGAAGCAG
CGAAGGCGTTCTATCTCAAACACGGCTTCATCGCCTCGCCCATCCACGATAGGACGGTGATGTTGCCGCTTAGGTGA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT182107 WP_004246828.1 NZ_CP065144:3574956-3575276 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT182107 NZ_CP086332:734207-734479 [Xanthomonas translucens pv. phleipratensis]
ATGAGCGCCGTCACCAGCAAAGTCATCAATTTTCGGGCGCCTGCTGCCAAACAGGCGCTGATCGACCACGCCGTGGAAGT
CAGCGGCATGAACCGCACAGAGTTCATCCTGGACGCCGTGTGCGAGAAGGCGCGCGAGGTGCTGGCCGACCAGACCCGAT
TCGCCCTGAGCCCGCAGCAGCTGCAGCGCTTCAATGCACTACTCGATGCGCCTCTGGAGAGTAATGCAGCGATCCGTCGC
CTGTTGAGCACGCCGGCGCCTTGGGAACACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References