Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 106870..108468 Replicon chromosome
Accession NZ_CP065144
Organism Proteus mirabilis strain PmBJ024

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag I0U44_RS00510 Protein ID WP_195858359.1
Coordinates 106870..108213 (-) Length 448 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag I0U44_RS00515 Protein ID WP_041701484.1
Coordinates 108217..108468 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I0U44_RS00490 102487..103671 + 1185 WP_004246423.1 multidrug efflux MFS transporter EmrD -
I0U44_RS00495 103781..105313 - 1533 WP_004246422.1 glycerol kinase GlpK -
I0U44_RS00500 105356..106171 - 816 WP_004246421.1 aquaporin -
I0U44_RS00505 106468..106710 + 243 WP_012368679.1 cell division protein ZapB -
I0U44_RS00510 106870..108213 - 1344 WP_195858359.1 type II toxin-antitoxin system HipA family toxin Toxin
I0U44_RS00515 108217..108468 - 252 WP_041701484.1 helix-turn-helix domain-containing protein Antitoxin
I0U44_RS00520 109044..109562 - 519 WP_004246419.1 ribonuclease E activity regulator RraA -
I0U44_RS00525 109671..110588 - 918 WP_049199260.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
I0U44_RS00530 110687..112027 - 1341 WP_004246417.1 HslU--HslV peptidase ATPase subunit -
I0U44_RS00535 112040..112570 - 531 WP_004246416.1 ATP-dependent protease subunit HslV -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(150-399)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 448 a.a.        Molecular weight: 49714.15 Da        Isoelectric Point: 5.3203

>T182104 WP_195858359.1 NZ_CP065144:c108213-106870 [Proteus mirabilis]
MKAQILSVAMNGDLVGKLTKNTDGGMSFQYAEEWLAEPGARAISLSLPLQKGRIIGSAVYNFFSNLLPDSEAIIDRMQIR
FKVKTNHPFDLLAAVGRDCVGAIQLYSPDTEIPSVMETHAEPLNENQIEELLDGYQTAPLGMSEDVDFRISLAGAQEKTA
LLWYQDCWQRPQGSTPTSHIFKLPIGLIEHHNIDLRESCENEWLCLCIAREFGFPVTNAELAIFGQKKVLIVERFDRKWS
SSGNWLLRLPQEDCCQALSVAPALKYESDGGPGIESIMTLLLGSQKAIDDREMFFKSQILFWMLAAIDGHGKNFSIFIES
GTSFRLTPLYDVMSAFPIFEARGIEIKKAKMAMALQGKNRQYNFSMIQPRHFISTATKVGFPTKTAMELMVDMAEKTDAV
IATVSSQLPADFPEHISNAIFSGLSIQADKIKRLSSGTSSQNMMVSN

Download         Length: 1344 bp

>T182104 NZ_CP086326:2433189-2433374 [Lacticaseibacillus rhamnosus]
TTGCAGCGTCAAGGTCATGTAAAATTAGCTTCTCTACATGACCATGCTTTAAAGGGTGCTCACAGCGGCGAACGAGCATT
GCGTGTTGCTCCTGATTGGCTTCTCGTTTATAAAGTCGATGCTGAAGCGTTAATTTTAATGCTTCTTGCAACAGGCACAC
ACCGCGATACATTGAACATTGAGTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9390.83 Da        Isoelectric Point: 9.8955

>AT182104 WP_041701484.1 NZ_CP065144:c108468-108217 [Proteus mirabilis]
MKITTPSMLAAAIHDLRKQSKLTQAQTAEQVGLRQATVSEFENNPESTKLETLFKILASLELELHVVKRGKNLSEGKVWN
KEW

Download         Length: 252 bp

>AT182104 NZ_CP086326:2432889-2433161 [Lacticaseibacillus rhamnosus]
ATGACCAAAAAATCCCGCATCAGCGTTAGGATTGATACCAAAACTAAAGAACGAGCGCTCCATGTTCTTAATAGCATGGG
ATTAGATATTTCCTCGGCTATTAACATGTACCTGAAACGGATTGGTGACACCGGTGCATTGCCATTTACACCTCCAATGT
CATTTGTTGATCAGCTTCAAGTTGCAGAAGCTGATGTTAAAGCGGGGCGAATAAAAAGCTTCAAGACTGTCGATGCTTTG
ATGAAGGATTTATACAGTGATGTTGACGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References