182097

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4658806..4659328 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name relE Uniprot ID A0A829L6G8
Locus tag I2T83_RS22400 Protein ID WP_001105433.1
Coordinates 4658806..4659096 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V0SC69
Locus tag I2T83_RS22405 Protein ID WP_000212715.1
Coordinates 4659086..4659328 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS22385 4653969..4655624 + 1656 WP_021523332.1 alpha,alpha-phosphotrehalase -
I2T83_RS22390 4656018..4658156 + 2139 WP_000187798.1 anaerobic ribonucleoside-triphosphate reductase -
I2T83_RS22395 4658341..4658805 + 465 WP_001009182.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
I2T83_RS22400 4658806..4659096 - 291 WP_001105433.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I2T83_RS22405 4659086..4659328 - 243 WP_000212715.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I2T83_RS22410 4659520..4659906 - 387 WP_001232246.1 cytochrome b562 -
I2T83_RS22415 4660090..4661442 - 1353 WP_001162173.1 metalloprotease PmbA -
I2T83_RS22420 4661536..4662087 + 552 WP_000166270.1 ribosome-associated protein -
I2T83_RS22425 4662239..4663612 - 1374 WP_001522402.1 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-72)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11367.23 Da        Isoelectric Point: 10.0238

>T182097 WP_001105433.1 NZ_CP065136:c4659096-4658806 [Escherichia coli]
MNYELAFDPRALKEWQKLGVTVREQFKKKLEDVLKRPRNPSAKLRDLPDCYKIKLRTQGYRLVYQVNDKELLVLVIAIGK
RENSAVYEDATKRLDE

Download         Length: 291 bp

>T182097 NZ_CP086305:c2348453-2348034 [Burkholderia ambifaria]
ATGATCCTCGTCGATACCAACGTTATTTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
GCAGAATGTCGAGACGCTGTTTCTTGCCGCGATCAGCCTCGCGGAAATGCGTTTCGGCGTGGCCGCGTTGCCGGAAGGGA
GAAGGCGGGACTGGCTGCACCAAAGCATCGAGCAGCGCGTCGTGCCGCTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCGGCCAGTAAAGCCTATGCGAGCCTTCGTGCGAAGGCTCGGGCCACGGGCAACGCGATGGCGTCTGCCGATGGATTTAT
CGCTGCAACGGCTGTGGCGAACGGGTTGATCGTGGCGACGCGTGACGTCGCGCCGTTCGAAGCGGCGGGCTTGCGCGTGA
TTGACCCATGGGCCCGGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9125.56 Da        Isoelectric Point: 5.1369

>AT182097 WP_000212715.1 NZ_CP065136:c4659328-4659086 [Escherichia coli]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAENGRMPVKTLTVSDSEEALLRTVRERLANPQEAIKVRLDEL

Download         Length: 243 bp

>AT182097 NZ_CP086305:c2348689-2348450 [Burkholderia ambifaria]
ATGCCGGTGATTACCGTTCGAAATTTGTCCGACGAGGTGCATCGCGCACTTCGCATCCGTGCGGCACAACATGGTCGGAG
TACCGAAGCGGAGGTGCGCGCCATCCTCGAGGAAGCCGTTCGGCCCGGCGGGCGGGCGAAGCTGGGGTCGCTGCTGGCTG
AAATCGGGCGGGAGGCGGGTGGTGTTGATTTCGAGATTCCGCGCGAGAGCTCGCCAACCGATCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829L6G8

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9H4B3

References