Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 920699..921534 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name yeeV Uniprot ID S1PMM7
Locus tag I2T83_RS04395 Protein ID WP_000854720.1
Coordinates 920699..921076 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A3B7PDS8
Locus tag I2T83_RS04400 Protein ID WP_001285612.1
Coordinates 921166..921534 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS04365 916659..917924 - 1266 WP_001218754.1 integrase arm-type DNA-binding domain-containing protein -
I2T83_RS04370 918388..918714 - 327 WP_000779482.1 type II toxin-antitoxin system RelE/ParE family toxin -
I2T83_RS04375 918711..918974 - 264 WP_001143297.1 type II toxin-antitoxin system ParD family antitoxin -
I2T83_RS04380 919046..919912 - 867 WP_001290180.1 DUF4942 domain-containing protein -
I2T83_RS04385 920005..920202 - 198 WP_000839238.1 DUF957 domain-containing protein -
I2T83_RS04390 920214..920702 - 489 WP_000777672.1 hypothetical protein -
I2T83_RS04395 920699..921076 - 378 WP_000854720.1 TA system toxin CbtA family protein Toxin
I2T83_RS04400 921166..921534 - 369 WP_001285612.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I2T83_RS04405 921614..921835 - 222 WP_000692347.1 DUF987 domain-containing protein -
I2T83_RS04410 921922..922398 - 477 WP_001186727.1 RadC family protein -
I2T83_RS04415 922414..922899 - 486 WP_000849596.1 antirestriction protein -
I2T83_RS04420 922954..923772 - 819 WP_047938428.1 DUF945 domain-containing protein -
I2T83_RS04425 923872..924105 - 234 WP_024173997.1 DUF905 family protein -
I2T83_RS04430 924191..924595 + 405 WP_000839179.1 IS66 family insertion sequence hypothetical protein -
I2T83_RS04435 924592..924939 + 348 WP_024173998.1 IS66 family insertion sequence element accessory protein TnpB -
I2T83_RS04440 924988..926526 + 1539 WP_000099193.1 IS66 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14089.02 Da        Isoelectric Point: 7.9087

>T182074 WP_000854720.1 NZ_CP065136:c921076-920699 [Escherichia coli]
MKTLPDTHVREASRCPSPVTIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGTSSQLINSIDILRARRATGLMTRDNYRTVNNITRGKHPEAKQ

Download         Length: 378 bp

>T182074 NZ_CP086298:308299-308715 [Burkholderia ambifaria]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGAAAGGGCAAGCGAGCCAACCGCGGCGTGCGCGCGTTCTTCAG
GCAGGCGGAGGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTGACGGTGGCCGAACTGCGGCGCGGCGTCGACCTGATCC
GTCATCGCGGCGATCATCCGCAGGCGTCCGCGCTCGAGGCATGGATGGCGACGATCCTGTCCGGCTATGCGTCGAACATC
CTGCCGGTCGATATCGAGACCGCCCAGATGTGGGGCCATTTGCGCGTGCCCGATCCGGCGCACGCCCTCGACCACCTGAT
CGCGGCCACCGCGCTGATCAACGATCTGACGGTCGTTACCCGCAATGTCGACGATTTCGCTCGCACCGGCGTCCGGCTGC
TGAACCCGTTCGATTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13663.44 Da        Isoelectric Point: 6.0618

>AT182074 WP_001285612.1 NZ_CP065136:c921534-921166 [Escherichia coli]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGRFSDADSYHLDQAFPLLMKQLELMLTSN
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYMAVYPTPETKK

Download         Length: 369 bp

>AT182074 NZ_CP086298:308076-308312 [Burkholderia ambifaria]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGACGGACATTCGCGCAAGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FW05

Antitoxin

Source ID Structure
AlphaFold DB A0A3B7PDS8

References