Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 819157..819991 Replicon chromosome
Accession NZ_CP065136
Organism Escherichia coli strain EE72d

Toxin (Protein)


Gene name yeeV Uniprot ID A0A0H2VDB0
Locus tag I2T83_RS03870 Protein ID WP_000854688.1
Coordinates 819157..819534 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A0H2VAY1
Locus tag I2T83_RS03875 Protein ID WP_001285596.1
Coordinates 819611..819991 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2T83_RS03840 814705..815639 - 935 Protein_753 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
I2T83_RS03845 815632..816027 - 396 WP_000208383.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
I2T83_RS03850 816096..816941 - 846 WP_001280441.1 DUF4942 domain-containing protein -
I2T83_RS03855 817225..818244 - 1020 WP_000875213.1 IS110 family transposase -
I2T83_RS03860 818458..818655 - 198 WP_000839260.1 DUF957 domain-containing protein -
I2T83_RS03865 818672..819160 - 489 WP_000761701.1 hypothetical protein -
I2T83_RS03870 819157..819534 - 378 WP_000854688.1 TA system toxin CbtA family protein Toxin
I2T83_RS03875 819611..819991 - 381 WP_001285596.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
I2T83_RS03880 820041..820685 - 645 WP_000094917.1 hypothetical protein -
I2T83_RS03885 820704..820925 - 222 WP_000692329.1 DUF987 domain-containing protein -
I2T83_RS03890 820988..821464 - 477 WP_001186726.1 RadC family protein -
I2T83_RS03895 821480..821965 - 486 WP_000849564.1 antirestriction protein -
I2T83_RS03900 822020..822838 - 819 WP_001234616.1 DUF945 domain-containing protein -
I2T83_RS03905 822939..823172 - 234 WP_001119727.1 DUF905 family protein -
I2T83_RS03910 823251..823706 - 456 WP_000581502.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14014.01 Da        Isoelectric Point: 8.5221

>T182073 WP_000854688.1 NZ_CP065136:c819534-819157 [Escherichia coli]
MKTLPDTHVRAASRCPSPVTIWQTLLTQLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SAGAPSQLINSIDILRARRATGLMTRNNYRMVNNITQGKHPEAKR

Download         Length: 378 bp

>T182073 NZ_CP086298:301612-301902 [Burkholderia ambifaria]
ATGCCACAAGTAATCTTTGCACCGGCGGCTATCCGAGACTTGCAGCGAATGCGCGATTTCCTGTTGTCGAAGAATCCTGA
CGCCGCGAGGCGGGCTGGCGAAGCGATTAGACGAGGCGTTCTGGCTCTCGGTACTCACCCTCGAATGGGACGCCTGATAG
AAGATTTCCCCGAGCAGTATCGGGAGTGGACCATCGATTTCGGAGATAGCGGTTACCTGGCCCGGTACCGCTTCGATGGC
GATACCGTCACGATCTTGGCTGTCCGACACCAGAAGGAAGCAGGGTATTGA

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 13897.70 Da        Isoelectric Point: 4.7959

>AT182073 WP_001285596.1 NZ_CP065136:c819991-819611 [Escherichia coli]
MSDTLPGTTLPDDNKDLPWWGLPCAVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Download         Length: 381 bp

>AT182073 NZ_CP086298:301346-301624 [Burkholderia ambifaria]
ATGGTTACGGCAACATCCATCAAGCTTGATGATGAATTGAAAGGGCGGGTTCAGCACTTGGCCGAAGCACGCCGACGTAC
CGCCCATTGGATCATGCGTGAGGCCATTGAGCAGTATGTCGAGCGCGAGGAAAAGCGCGAGGCGTTGAATCAGGACACGC
TCAAGGCATGGGATGAATTTCAGGCGACTGGCCTGCACGCGACCGCTGAGGAAGTGGACAAGTGGCTCGCGAGTTGGGGA
ACTGAAAACGAATTGCCCTCGCCGGAATGCCACAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H2VDB0

Antitoxin

Source ID Structure
AlphaFold DB A0A0H2VAY1

References