Detailed information of TA system TA182067

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 825510..825993
• Replicon: chromosome
• Accession: NZ_CP065060
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ28

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A922NVR0
• Locus tag: I2436_RS03920
• Protein ID: WP_021320634.1
• Coordinates: 825733..825993 (+)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A922NW74
• Locus tag: I2436_RS03915
• Protein ID: WP_012678125.1
• Coordinates: 825510..825731 (+)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2436_RS03890	822046..822312	+	267	WP_043029606.1	hypothetical protein	-
I2436_RS03895	822495..822950	-	456	WP_043029607.1	DUF1694 domain-containing protein	-
I2436_RS03900	823182..824489	+	1308	WP_012515409.1	phosphopyruvate hydratase	-
I2436_RS03905	824728..824817	+	90	WP_111677961.1	type I toxin-antitoxin system Fst family toxin	-
I2436_RS03910	825064..825300	-	237	Protein_740	transposase	-
I2436_RS03915	825510..825731	+	222	WP_012678125.1	hypothetical protein	Antitoxin
I2436_RS03920	825733..825993	+	261	WP_021320634.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I2436_RS03925	826073..827049	+	977	Protein_743	IS3 family transposase	-
I2436_RS03930	827050..827304	+	255	Protein_744	HAD family hydrolase	-
I2436_RS03935	827774..830554	+	2781	WP_206153124.1	endonuclease/exonuclease/phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	826073..826588	515

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10258.78 Da
• Isoelectric Point: 9.6925

>T182067 WP_021320634.1 NZ_CP065060:825733-825993 [Streptococcus equi subsp. zooepidemicus]
MYHIEYSKKAQKQIKKLDKQIQRLLFAWIDKHLEGTDNPRANGKGLAGNHANEWRYRIGDYRLICDIQDDKMVILALEFG
HRRDVY

Nucleotide

• Length: 261 bp

>T182067 NZ_CP086295:c1768150-1767767 [Burkholderia sp. B21-007]
ATGAGCGTTCTGGTCGACACGTCGGTCTGGGTCGAGCATTTCCGACGGCCGCTTCCTGCACTTATCCAGCTACTGCTGGC
GGACGACGTCTTGACGCATCCGCTTGTGATGCTCGAACTCACGTGCGGGACGCCGCCCGAACCGCGAGCCCGAACACTGG
GAGATCTCGCGCTGTTGCGCCAAACGCGCCTTGCGACGTCAGGTGAAGTCGCGGACTGGATCGAGCGGGAACGGCTGTAT
GGGCGCGGATGCGGTGCCGTAGATTGCACGCTGCTGGCGTCGGTGCTATTGACTCCGCGCACTTGGCTCTGGACGCGCGA
TCGGCGGCTCGCGCAAGTGGCGGACCAATTCGGGGTTCAGTACATACCGCCCGACCTGCATTGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8506.54 Da
• Isoelectric Point: 4.6104

>AT182067 WP_012678125.1 NZ_CP065060:825510-825731 [Streptococcus equi subsp. zooepidemicus]
MGTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKLYHQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT182067 NZ_CP086295:c1768353-1768147 [Burkholderia sp. B21-007]
ATGCGTACTACCGTCACCGTCGACGACACTCTCTATGCGCGCGCACTCGAACTCGCCGAGCCGGGTATTCCGCCGGCGGA
CCTGTTCCGGGCCGCACTGGAAACGTTCGTACGTGTCCAGGCCGGCCAACGCCTTGCCGCCCTTGGCGGTCGCGCCCCCG
ACATGCCTGATGTGCCGCGCCGGAACCCGACTGCTGCTGACCGATGA