Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1873018..1873633 Replicon chromosome
Accession NZ_CP065059
Organism Streptococcus equi subsp. zooepidemicus strain SEZ25

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag I2435_RS09020 Protein ID WP_043031456.1
Coordinates 1873018..1873356 (-) Length 113 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag I2435_RS09025 Protein ID WP_043031459.1
Coordinates 1873346..1873633 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2435_RS09000 1869074..1870084 + 1011 WP_206156444.1 UDP-glucose 4-epimerase GalE -
I2435_RS09005 1870161..1871204 + 1044 WP_206156445.1 galactose mutarotase -
I2435_RS09010 1871434..1871649 + 216 WP_158306821.1 transposase -
I2435_RS09015 1872304..1872426 + 123 WP_158306822.1 hypothetical protein -
I2435_RS09020 1873018..1873356 - 339 WP_043031456.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I2435_RS09025 1873346..1873633 - 288 WP_043031459.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
I2435_RS09030 1873845..1874066 + 222 WP_042669952.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
I2435_RS09035 1874063..1874470 + 408 WP_042669951.1 type II toxin-antitoxin system death-on-curing family toxin -
I2435_RS09040 1874667..1876100 - 1434 WP_043031460.1 putative DNA binding domain-containing protein -
I2435_RS09045 1876191..1877516 + 1326 WP_043031462.1 restriction endonuclease subunit S -
I2435_RS09050 1877566..1878363 + 798 WP_043031464.1 tyrosine-type DNA invertase PsrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1872304..1872426 122


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(11-91)


Sequences

Toxin        


Download         Length: 113 a.a.        Molecular weight: 13117.88 Da        Isoelectric Point: 4.6413

>T182066 WP_043031456.1 NZ_CP065059:c1873356-1873018 [Streptococcus equi subsp. zooepidemicus]
MAYDIYISNKAEQDLDDIYNYYLTEFSQSSAQKVIESLQSAISILELSPEGYVDFDARLGRKLFPEGQLRMIPSKHFIVF
YLIHQSRVDILRIRSTKTDYLNDLENLFNNIV

Download         Length: 339 bp

>T182066 NZ_CP086295:893520-893936 [Burkholderia sp. B21-007]
GTGTTTTTGATTGATACGAACGTCATCAGCGAGATCAGGAAGGGCAAGCGAACCAACCGCGGCGTGCGCGCGTTCTTCAG
GCAGGCGGAAGCCGACGCGAGCCCGCTTTACCTGTCGGTCGTGACGGTGGGCGAACTGCGGCGGGGCGTCGACCTGATCC
GTCATCGCGGCGATCATCCGCAGGCGTCGGCGCTCGAGGCATGGATGGCGACGATCCTGTCCGGCTATGCGTCGAACATT
CTGCCGGTCGATCTCGAGACCACCCAGATGTGGGGCCATTTGCGCGTGCCCGATCCGGCGCACGCCCTCGATAAACTGAT
CGCGGCCACCGCGCTGATCAACGATCTGACGGTCGTCACCCGCAATGTCGACGATTTCGCTCGCACCGGCGTCCAGTTGC
TGAACCCGTTCGATTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10949.45 Da        Isoelectric Point: 4.5718

>AT182066 WP_043031459.1 NZ_CP065059:c1873633-1873346 [Streptococcus equi subsp. zooepidemicus]
MATLTRDRQYNFRVNTEMLEEAKRILESKNISVPDALNLFVERVVEEKDLPIKTTEQIRAESFLNELISELDAGYQDVLV
GRTKPANEVFSKYGL

Download         Length: 288 bp

>AT182066 NZ_CP086295:893297-893533 [Burkholderia sp. B21-007]
ATGGCAAATCTTCTGGTGCGTAACGTGGATGACAGTATCGTTCAGAGCCTGCGCGAGCAGGCCGCGGCCAACGGCAGGAG
CGCCGAGGCCGAACATCGGGCCATTCTGGCCGAGGCGCTCGGCCGGCCGAAGCGACGGACATTCGCGCAAGTGCTGATGA
GCATGCCGGACGTCGGCGAAGACGCGGATTTCCAACGTGTTCAGGATTCCGGCGAGGTCAGGCGTGTTTTTGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References