Detailed information of TA system TA182065

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1293262..1293745
• Replicon: chromosome
• Accession: NZ_CP065059
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ25

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I2435_RS06395
• Protein ID: WP_043983658.1
• Coordinates: 1293262..1293522 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B4U2B9
• Locus tag: I2435_RS06400
• Protein ID: WP_012515410.1
• Coordinates: 1293524..1293745 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2435_RS06385	1290445..1291050	-	606	WP_151374890.1	HAD-IA family hydrolase	-
I2435_RS06390	1291566..1292914	+	1349	WP_151374889.1	IS3 family transposase	-
I2435_RS06395	1293262..1293522	-	261	WP_043983658.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I2435_RS06400	1293524..1293745	-	222	WP_012515410.1	hypothetical protein	Antitoxin
I2435_RS06405	1293955..1294191	+	237	Protein_1205	transposase	-
I2435_RS06410	1294327..1295634	-	1308	WP_012515409.1	phosphopyruvate hydratase	-
I2435_RS06415	1295718..1295864	-	147	WP_154231399.1	hypothetical protein	-
I2435_RS06420	1295855..1296310	+	456	WP_043983659.1	DUF1694 domain-containing protein	-
I2435_RS06425	1296561..1297816	+	1256	WP_043983297.1	ISL3 family transposase	-
I2435_RS06430	1297911..1298186	-	276	WP_012515407.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (3-85)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10252.83 Da
• Isoelectric Point: 9.3537

>T182065 WP_043983658.1 NZ_CP065059:c1293522-1293262 [Streptococcus equi subsp. zooepidemicus]
MYRIEYSKKAQKQIKKVDKQIQRLLFAWIDKYLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVILALEFG
HCKDIY

Nucleotide

• Length: 261 bp

>T182065 NZ_CP086295:613634-614530 [Burkholderia sp. B21-007]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCGTTCGCCGCGCTGCTCGGGCAATTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGTTATCGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGCTGCCCGTCGTGCTGC
TGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGACGCGTGCTTGCGTGG
GATGCGCCCGGCTACGGCGTGTCGACCCCGGTGCACGGCGCGTCGCCGACCGCCGCCGATTACGCGGCGTCGCTGAACGC
GTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCGCGGGCGGCTTGTCCC
GCCTGATGCCCGCGCGGATCGCTGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGCGCGCCCGCCGAAACGCGC
GACACGCGCCGCGACGCGCGCCTCGCGATGCTCGAGGCACTCGGTCCGGCCGGGCTCGCCGAGCAGCGCAGCGGCAACAT
GCTGTCGGGTTTTGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGCATCGTGCCGGCCGGCTATGCAC
AGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGCCGCACGGCCGTGGCCGTCGGC
GCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAGCTGCAGGTGATTCCGCA
GGCCGGCCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCGTCGCTCATCGACGCGTTCTGCCGTCAGTGCGACACGC
AGCGAGGTATGGCATGA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8536.57 Da
• Isoelectric Point: 4.6104

>AT182065 WP_012515410.1 NZ_CP065059:c1293745-1293524 [Streptococcus equi subsp. zooepidemicus]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKIYHQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT182065 NZ_CP086295:614527-615384 [Burkholderia sp. B21-007]
ATGAGCGAACCGCTGCAACAACCAGAATCCGAGAGCACCAAGGCCGACGCCGGCTACGTGGTGCCGGGCCTCGAACGCGG
CCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCGGACAAGGACCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGTCTGCCGGTGATCGA
GAGCCTGCGCGACGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGGGTTCAGCGCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGGGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGACGCGCTGTACGAAGTGATCCGCGAGGATGCGCTGCGCGGCTACGGCATCAGCAATTCGTCGTTCG
AGCGCGGTATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAAATCGACGCGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTGAAGGCTTTAGGACTCCGATGA

Structures

Antitoxin

• AlphaFold DB: A0A380KCN4