Detailed information of TA system TA182064

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sezT-pezT/zeta-couple_hipB
• Location: 1515860..1517097
• Replicon: chromosome
• Accession: NZ_CP065058
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ18

Toxin (Protein)

• Gene name: sezT
• Uniprot ID: -
• Locus tag: I2434_RS07085
• Protein ID: WP_165623639.1
• Coordinates: 1515860..1516621 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: I2434_RS07090
• Protein ID: WP_165623640.1
• Coordinates: 1516621..1517097 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2434_RS07065	1511880..1512272	-	393	Protein_1367	relaxase/mobilization nuclease domain-containing protein	-
I2434_RS07070	1512259..1512624	-	366	WP_012678608.1	MobC family plasmid mobilization relaxosome protein	-
I2434_RS07075	1512634..1512993	-	360	WP_165623491.1	hypothetical protein	-
I2434_RS07080	1513311..1515818	-	2508	WP_206157586.1	AAA family ATPase	-
I2434_RS07085	1515860..1516621	-	762	WP_165623639.1	zeta toxin family protein	Toxin
I2434_RS07090	1516621..1517097	-	477	WP_165623640.1	helix-turn-helix domain-containing protein	Antitoxin
I2434_RS07095	1517167..1517454	-	288	WP_165623641.1	hypothetical protein	-
I2434_RS07100	1517499..1517893	-	395	Protein_1374	chemotaxis protein	-
I2434_RS07105	1517897..1518121	-	225	WP_165623642.1	hypothetical protein	-
I2434_RS07110	1518175..1519261	-	1087	Protein_1376	toprim domain-containing protein	-
I2434_RS07115	1519301..1519939	-	639	WP_165623643.1	peptidylprolyl isomerase	-
I2434_RS07120	1520121..1521635	-	1515	WP_038674112.1	ABC transporter ATP-binding protein/permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	1492781..1540376	47595

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (23-213)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 28763.80 Da
• Isoelectric Point: 6.7604

>T182064 WP_165623639.1 NZ_CP065058:c1516621-1515860 [Streptococcus equi subsp. zooepidemicus]
MRLEEFSKDDFDLALKRTIRSLTRGTTTSVTPKAILLGGQSGAGKTTIHRIKQKEFQGNIIIIDGDSYRSLHPNYLALQE
EYGKDSVDYTKGFAGKMVEHLVDELSKQGYHLLIEGTLRTTEIPRKTARLLKARGYQVSLALIATKPELSYLSTLIRYEE
VYVVNPSQARATPKEHHDGIVEYLVSNLRKLETDKLFDQIQIYQRDRTCVYDSGMDEGSAADVLQDCLFGKWSKVEEEML
KVGEEQLNELLKK

Nucleotide

• Length: 762 bp

>T182064 NZ_CP086295:403489-403908 [Burkholderia sp. B21-007]
ATGATCCTCGTCGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
GCAGAATGTCGAGACGCTGTTTCTTGCCGCGATCAGCCTCGCGGAAATGCGCTTCGGCGTGGCCGCGTTGCAGGAAGGGC
GAAGGCGGGACTGGCTGCACCAAAGCATCGAGCATCGCGTCGTGCCGCTGTTTCGCGGCCGGATCCTGCCGTTCGACGAT
GCGGCCAGTAAAGCGTATGCGAGCCTTCGCGCGAAGGCTCGTGTTACGGGCAACGCGATGGCGTCTGCCGATGGATTGAT
CGCTGCAACGGCCGCGGCGAACGGCTTGATCGTGGCGACGCGTGACGTCGTGCCGTTCGAAGCGGCGGGCTTGCGCGTGA
TCGACCCGTGGGCCCGATAA

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18125.47 Da
• Isoelectric Point: 4.3858

>AT182064 WP_165623640.1 NZ_CP065058:c1517097-1516621 [Streptococcus equi subsp. zooepidemicus]
MIGDNIKSLRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYVDIVGEEKMLTPVEDYQLTLKIE
VIKERGAAILSQLYRYQDSQGIAFDDETNPWILMSDDLSDLINTKIYLVDTFDEVERYNGYLDGIERMLELAHHQVVA

Nucleotide

• Length: 477 bp

>AT182064 NZ_CP086295:403253-403492 [Burkholderia sp. B21-007]
ATGCCGGTTATTACCGTTCGAAATTTGCCCGACGAGGTGCATCGCGCGCTTCGCGTCCGTGCGGCGCAACATGGTCGCAG
TACCGAAGCGGAGGTGCGCGCCATCCTCGAGGAGGCCGTTCGGCCCGGCGGGCGGGCGAAGCTTGGGACGCTGCTGGCCG
AAATCGGGCGCGAGGCGGGTGGTGTCGATTTCGAGATTCCGCGCGAGAGCGCGCCAATCGATCCGATGAGCTTCGAATGA