Detailed information of TA system TA182063

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1312473..1312956
• Replicon: chromosome
• Accession: NZ_CP065056
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ14

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I2433_RS06395
• Protein ID: WP_206151951.1
• Coordinates: 1312473..1312733 (-)
• Length: 87 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A7Z8ZWG7
• Locus tag: I2433_RS06400
• Protein ID: WP_021320633.1
• Coordinates: 1312735..1312956 (-)
• Length: 74 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2433_RS06385	1307839..1310619	-	2781	WP_206151950.1	endonuclease/exonuclease/phosphatase family protein	-
I2433_RS06390	1311090..1311695	-	606	WP_206152567.1	HAD-IA family hydrolase	-
I2433_RS06395	1312473..1312733	-	261	WP_206151951.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
I2433_RS06400	1312735..1312956	-	222	WP_021320633.1	hypothetical protein	Antitoxin
I2433_RS06405	1313165..1313401	+	237	Protein_1198	transposase	-
I2433_RS06410	1313537..1314844	-	1308	WP_012515409.1	phosphopyruvate hydratase	-
I2433_RS06415	1315076..1315531	+	456	WP_043025632.1	DUF1694 domain-containing protein	-
I2433_RS06420	1315713..1315976	-	264	WP_012678127.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-86)

Antitoxin

• Protein of unknown function DUF6290 (1-71)

Sequences

Toxin

Protein

• Length: 87 a.a.
• Molecular weight: 10260.79 Da
• Isoelectric Point: 9.6749

>T182063 WP_206151951.1 NZ_CP065056:c1312733-1312473 [Streptococcus equi subsp. zooepidemicus]
MYHIEYSKKAQKQIKKLDKQIQRLLFAWIDKHLEGTDNPRANGKGLTGNHANEWRYRIGDYRLICDIQDDKMVVLALEFG
HRKDIY

Nucleotide

• Length: 261 bp

>T182063 NZ_CP086295:c251102-250521 [Burkholderia sp. B21-007]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGCAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGACGGGCCGTCCCGAAAGCACGGCGGAGCACAGCTGGCGTCTCTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGACGTCGACACGACGAAGCTGCTGAAATTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCGCGAACGCGACGACCTGCTGACGCTCACGGCCGGGCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCACCGGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGGCTAC
GGGCGGCGCTACACCGACGCGACGCCGCTGTTCGGCGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCCGGATCGA
CGCACGCGGCGACGGCGCGTAA

Antitoxin

Protein

• Length: 74 a.a.
• Molecular weight: 8536.57 Da
• Isoelectric Point: 4.6104

>AT182063 WP_021320633.1 NZ_CP065056:c1312956-1312735 [Streptococcus equi subsp. zooepidemicus]
MSTVTIRLNQEEEIFFKSYAQLTGQSLSSLFKKALERDIEDEYDLKLYHQAYAEYKADPETISHADFKKELGL

Nucleotide

• Length: 222 bp

>AT182063 NZ_CP086295:c251768-251211 [Burkholderia sp. B21-007]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAATTGTTCGGTGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGACTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCATCGTCTGCTCGCCTGTTCGCCGTCGCGCGCGGCCGAGTTCTC
ACGGCCGCTGCCGGCGTTGCTCGGTACCTCGCTGTGGCGCTATGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCGGGACCGCCGAGCGTCGAATTCGCGACCGGCACCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCAGCACCTGCCGGTGGACGCGCATGACGCTATCGGACGGCTCTGCCGCGCGGCTCGTCGAAACGCTGTAG

Structures

Antitoxin

• AlphaFold DB: A0A7Z8ZWG7