Detailed information of TA system TA182062

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 1007853..1008340
• Replicon: chromosome
• Accession: NZ_CP065054
• Organism: Streptococcus equi subsp. zooepidemicus strain SEZ13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: I2432_RS04775
• Protein ID: WP_138119189.1
• Coordinates: 1008083..1008340 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: I2432_RS04770
• Protein ID: WP_138119187.1
• Coordinates: 1007853..1008086 (+)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2432_RS04730	1003614..1003814	+	201	WP_206159042.1	hypothetical protein	-
I2432_RS04735	1003807..1004604	+	798	WP_138119175.1	PD-(D/E)XK nuclease-like domain-containing protein	-
I2432_RS04740	1004782..1005123	+	342	WP_138119177.1	hypothetical protein	-
I2432_RS04745	1005120..1005632	+	513	WP_138119179.1	crossover junction endodeoxyribonuclease RuvC	-
I2432_RS04750	1005857..1006513	+	657	Protein_908	DUF1642 domain-containing protein	-
I2432_RS04755	1006510..1006677	+	168	WP_206159043.1	hypothetical protein	-
I2432_RS04760	1006674..1007054	+	381	WP_206159044.1	hypothetical protein	-
I2432_RS04765	1007246..1007683	+	438	WP_138119185.1	DUF1492 domain-containing protein	-
I2432_RS04770	1007853..1008086	+	234	WP_138119187.1	antitoxin	Antitoxin
I2432_RS04775	1008083..1008340	+	258	WP_138119189.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I2432_RS04780	1008413..1008751	+	339	WP_138119191.1	hypothetical protein	-
I2432_RS04785	1008741..1010015	+	1275	WP_206159045.1	PBSX family phage terminase large subunit	-
I2432_RS04790	1010015..1011316	+	1302	WP_138119195.1	phage portal protein	-
I2432_RS04795	1011309..1012217	+	909	WP_138119197.1	minor capsid protein	-
I2432_RS04800	1012545..1013114	+	570	WP_138119199.1	DUF4355 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	995586..1076282	80696

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

• Protein of unknown function DUF6290 (1-57)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9926.74 Da
• Isoelectric Point: 10.6548

>T182062 WP_138119189.1 NZ_CP065054:1008083-1008340 [Streptococcus equi subsp. zooepidemicus]
MSYKLIPTPLFAKQFKKLDKFVQKQIKSYLEKVLSDPRAKGKGLVANRSGQWRYRIGDYRVIVNIQDGEMIVLALEVGHR
KDIYK

Nucleotide

• Length: 258 bp

>T182062 NZ_CP086294:1766650-1767072 [Burkholderia sp. B21-007]
GTGACGACGCTCTACATGCTCGATACGAACATCTGTTCGTTCATCATGCGCGAGCGGCCATCCGCGGTGTTGTCCCGGTT
GCAGTCGTGCGTCAATGCGCAGCACCGGATCGTCGTGTCGGCGATCACCTATGCCGAAATGCGGTTCGGCGCAGTCGGCA
GAAAGGCGTCGCCGAAGCATGCGGAACTCGTGACGGCCTTTGTCACGCGGCTGGATGGCGTGCTGTCGTGGGACACCGCG
GCAGTCGATGCAACGGCCGCGATTCGCGTCGACCTTGCCGCACGTGGCACGCCGATCGGCGCGAACGACGCGTCGATCGC
CGGTCACGCGATCGCGGCCGGTGCCGTGCTTGTAACGAACAACAGTCGCGAATTCAGCCGTGTCGCGGGGTTGTCGCTCG
AAGACTGGGCAGCCTCGGCCTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8731.96 Da
• Isoelectric Point: 4.1196

>AT182062 WP_138119187.1 NZ_CP065054:1007853-1008086 [Streptococcus equi subsp. zooepidemicus]
MAVITLKISEQEKSFLQGMAKFEGISLSELIRKKTLKSLEDEYDARVADMALEDYENYLENGGQVLSWAALMNEVDL

Nucleotide

• Length: 234 bp

>AT182062 NZ_CP086294:1766387-1766653 [Burkholderia sp. B21-007]
ATGCGCACCGTTTCCATTTTCAAGAACGCCCGTAACCAGGCAATCCGCATCCCGAAGGACATGGAGTTCGAGGGTGTGAC
GGAACTCGAGATCCGCCGCGAGGGCGACACGTTGCTGCTGCGTCCGGTGCGGCCGACGTGGCTGTCGTTCGCGAGTGAAC
CACGGGCCGATGCCGACTTCCTCGTCGAGCGCCCGACGGTCGTCGAACTTGGTCGTTTCGACCTGCCCGGCGCCGATGAC
GATGCACCGACGGAGTCGAACCGGTGA