Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpB-mazE/PRK09812-MazE
Location 36653..37245 Replicon chromosome
Accession NZ_CP065053
Organism Massilia sp. CCM 8941

Toxin (Protein)


Gene name chpB Uniprot ID -
Locus tag IV454_RS00140 Protein ID WP_206089663.1
Coordinates 36653..37000 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag IV454_RS00145 Protein ID WP_206089664.1
Coordinates 36994..37245 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IV454_RS00115 32217..32981 - 765 WP_206089658.1 site-2 protease family protein -
IV454_RS00120 33036..33670 - 635 Protein_23 threonylcarbamoyl-AMP synthase -
IV454_RS00125 33667..34551 - 885 WP_206089660.1 protease HtpX -
IV454_RS00130 34698..35531 - 834 WP_206089661.1 PHP domain-containing protein -
IV454_RS00135 35611..36486 - 876 WP_206089662.1 alpha/beta hydrolase -
IV454_RS00140 36653..37000 - 348 WP_206089663.1 type II toxin-antitoxin system ChpB family toxin Toxin
IV454_RS00145 36994..37245 - 252 WP_206089664.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
IV454_RS00150 37384..38532 - 1149 WP_206089665.1 hypothetical protein -
IV454_RS00155 38722..39246 + 525 WP_206089666.1 gamma carbonic anhydrase family protein -
IV454_RS00160 39250..40206 + 957 WP_206089667.1 Hsp33 family molecular chaperone HslO -
IV454_RS00165 40208..40642 + 435 WP_206089668.1 thioesterase family protein -
IV454_RS00170 40649..41182 + 534 WP_206089669.1 GNAT family N-acetyltransferase -
IV454_RS00175 41301..41489 - 189 WP_206089670.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(9-113)

Antitoxin

SpoVT-AbrB domain

(6-48)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12186.12 Da        Isoelectric Point: 10.9254

>T182059 WP_206089663.1 NZ_CP065053:c37000-36653 [Massilia sp. CCM 8941]
VVKRAKFGRGDIILVNLDPTKGHERQGMRPALVLSTSVFNALGLALVAPIAQGGDFARHAGFAAPLTGSGTTIQGVVLVN
QVRMLDLEARAARRVETAPEFVVDDALARLRAITD

Download         Length: 348 bp

>T182059 NZ_CP086292:1834385-1834684 [Burkholderia ambifaria]
ATGGACAAGATCAAGACCCGGCCGTGGGATTCGGCCGAACACCTGAAAACCGACGACGACATGGCCGACTACTTCGAGGC
CTGTCTGCAGGAAGCCGGCGACGACCCGGCCTTCATCGCGCATGCGCTCGGCGTGATCGCCCGTGCGCGCGGCATGTCGC
AGGTCGCGCGCGACGCGGGCCTGTCGCGCGAAGGGCTGTACAAGGCGCTGTCGCACGACGGCAATCCGAGCTTCGGCACG
ATCCTGAAAGTGATCAAGGCGCTCGGCCTGCAACTGCACGGCGCGAAGGCGCACGCGTGA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 8902.30 Da        Isoelectric Point: 4.9431

>AT182059 WP_206089664.1 NZ_CP065053:c37245-36994 [Massilia sp. CCM 8941]
MELSVQKWGNSAAVRLPTELLGILKATLGDKLTVSVQNEGVLLKVKRPAYSLADLVAQCDPSAPEPVDMAAWSNVTPVGR
EAW

Download         Length: 252 bp

>AT182059 NZ_CP086292:1834064-1834381 [Burkholderia ambifaria]
ATGCCATACAGTGCACCAACATTCAGTATCCGGACCACCGACGTCTTCGACGCGTGGTTTGCCGGCCTGCAGGATCGCGT
CGCGAAGCGCCGCATCCAGGCGCGCATCGACCGTCTGTCGATGGGCAATCCGGGCGACTGGAAATCCGCCGGCTCCCCCG
TCGTCGAAATGCGTATCGACCACGGGCCCGGCTATCGCGTCTACTACGTCAGGCGCGGAACGATATGGGTGATCCTGCTC
TGCGGCGGCGACAAGTCGACGCAACAGGGGGACATCCGCGCCGCGCACGCGATGCTCGCGCGGCTCGACCTGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References