182057

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 4654..5239 Replicon plasmid p5637
Accession NZ_CP065052
Organism Acinetobacter baumannii strain 2016GDAB1

Toxin (Protein)


Gene name brnT Uniprot ID N9M3U8
Locus tag IVB58_RS18370 Protein ID WP_005155676.1
Coordinates 4654..4941 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID N9LW73
Locus tag IVB58_RS18375 Protein ID WP_005155677.1
Coordinates 4928..5239 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB58_RS18340 (IVB58_18295) 274..1050 + 777 WP_005166158.1 ParA family protein -
IVB58_RS18345 (IVB58_18300) 1069..1968 + 900 WP_005166156.1 ParB/RepB/Spo0J family partition protein -
IVB58_RS18350 (IVB58_18305) 2095..2331 + 237 Protein_2 IS4 family transposase -
IVB58_RS18355 (IVB58_18310) 2392..3092 + 701 Protein_3 IS1 family transposase -
IVB58_RS18360 (IVB58_18315) 3121..3312 + 192 Protein_4 IS4 family transposase -
IVB58_RS18365 (IVB58_18320) 3318..4351 - 1034 Protein_5 ISNCY family transposase -
IVB58_RS18370 (IVB58_18325) 4654..4941 + 288 WP_005155676.1 BrnT family toxin Toxin
IVB58_RS18375 (IVB58_18330) 4928..5239 + 312 WP_005155677.1 BrnA antitoxin family protein Antitoxin
IVB58_RS18380 (IVB58_18335) 5318..6409 - 1092 Protein_8 IS4 family transposase -
IVB58_RS18385 (IVB58_18340) 6650..7612 + 963 WP_243491848.1 TIGR00341 family protein -
IVB58_RS18390 (IVB58_18345) 7659..8363 + 705 WP_001067783.1 IS6-like element IS1008 family transposase -
IVB58_RS18395 (IVB58_18350) 8418..9857 + 1440 Protein_11 IS91-like element ISCR1 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid dfrA19 / ARR-3 / qacE / sul1 / aph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / floR / tet(Y) - 1..72156 72156
- inside IScluster/Tn dfrA19 / ARR-3 / qacE / sul1 / aph(3'')-Ib / aph(6)-Id / mph(E) / msr(E) / tet(39) / floR / tet(Y) - 2092..38390 36298


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11275.66 Da        Isoelectric Point: 5.6113

>T182057 WP_005155676.1 NZ_CP065052:4654-4941 [Acinetobacter baumannii]
MEQYFEWDEAKNRKNQKKHDISFETASLVFEDPLRISIQDRHTNGEERWQTIGKVKGVLMLLVAHTIFDEDDCEIIRIIS
ARQVTKAERNQYEHG

Download         Length: 288 bp

>T182057 NZ_CP086292:c1458047-1457136 [Burkholderia ambifaria]
ATGAGTGTCATCGACAAACGTGAACGCGACCGCACCGCGGCATTCGCCGCGCTGCTCGGGCAGTTTCCCGAACAGCGCTG
CGCGGCCGGCGCGGCGGGCACGATCGGCTACCGTGAGGCTGGCGCAGGCGAGGCCGGCGCGCAGCATGCGGGCCACGCGC
TGCCCGTCGTGCTGCTGCACGGGATCGGCTCGGGCGCCGCATCGTGGGTGTGCCAGCTCGACACGCTCGGCGCGTCGCGA
CGCGTGCTTGCGTGGGATGCGCCCGGCTACGGCGTGTCGACCCCCGTGCACGGCGCATCGCCGACCGCCGCCGATTACGC
GGCGTCGCTGAACGCGTGGCTCGAGGCACTCGGCATCGAACGCTGCGTGCTGGTCGGGCATTCGCTCGGCGCGATCATCG
CGGGCGGCCTGTGCCGCCTGATGCCCGCGCGGATCGCCGGCCTGCTGCTGATCTCGCCCGCGGGCGGCTACGGCCGCGCG
CCCGCCGAAACGCGCGACACGCGCCGCGACGCGCGCCTCGCGATGCTCGCGGAACTCGGTCCGGCCGGGCTCGCCGAGCA
GCGCAGCGGCAACATGCTGTCGGGTTTCGCGAGCGAGGATGCGCGTGCGTGGGTGCGCTGGAACATGGCGCGTATCGTGC
CGGCCGGCTATGCGCAGGCCACGCATCTGCTCGCGAACGCCGATCTCGCGACCGATCTCGCCGGCTTTCGCGGTCGCACG
GCCGTGGCCGTCGGTGCGAACGACGCGATCACGCCGCCCGCCGCGTGCGAGCGGATCGCCGCGGCCGCGCAGGTCGAGCT
GCAGGTGATTCCGCAGGCCGGTCATGCCGGCTACGTGGAAGCGCCGGCCGTCTATTCGTCGCTCATCGACACGTTCTGTC
GTCAGTGCGACACGCAGCGAGGCATGGCATGA

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 11984.58 Da        Isoelectric Point: 6.7277

>AT182057 WP_005155677.1 NZ_CP065052:4928-5239 [Acinetobacter baumannii]
MSMVRYTREELNENFSNKQDAEVEHLLAKGTVPDDQLDLSDIPEITDWSNAIRHGQFFRPVKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLKDLKNH

Download         Length: 312 bp

>AT182057 NZ_CP086292:c1457139-1456282 [Burkholderia ambifaria]
ATGAGCGAACCGCTGCAACAACCAGAATCCGACAGCACCAAGGCCGACGCCGGCTATGTGGTGCCGGGCCTCGAACGCGG
CCTGCGGATCCTCGCCGAATTCTCGCCGCGCGAGCCGGTGCTCGGCGCGCCGGAGCTGTCCAAGCGCCTCGGCATTCCGC
GCACGACGGTGTTCCGTCTGCTGCAGACGCTCGAATCGCTCGGCTTTCTCGAGCGGGCGGACAAGGATCGCAACTACAAG
CTCGGCATCGCCGTGCTGCGGCTCGGCTTCGAATACCTGAGCTCGCTGGAGTTGACCGATCTCGGCCTGCCGGTGATCGA
GAGCCTGCGCGATGCGACCGGCTTCACGACGCACATCGTGATCCGCGACGGCCGCGACGTGGTGTTCGTCGCGAAGGCGC
AGTGCCAGTCGCCGGTATTCAGCGCGATTCGCGTGAACGTCGGCACGCGGCTGCCCGCGCATGCGACGACCCACGGCCAC
GTGCTGATGGGCGACCTGTCGCTGAAGGAGCTGCGTGCGCTGTATCCGGAAGGCACGCTGAGCCGGATGACGAGCGCGAC
GCCGGAAACGGTCGATGCGTTGTACGAAATGATCCGCGAGGATGCGCTGCGCGGCTACGGCGTCAGCAATTCGTCGTTCG
AGCGCGGCATCTCGGTGGTCACGGCGCCGGTGCGCAACGACACGCAGAAGATCGTCGCGTGCATCACGGTGACGGTGCCG
CGGCCGGAGATCGACGAGGCGCTGATCGCCGACGGCCTGTTCGACAAGGTGCAGCGCGCGGCGGCGGAACTGTCGCGGCG
GCTCAATTACCGCTCGGATGACGAGCACACGTTTCTCAAAGCTTTAGGACTCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB N9M3U8

Antitoxin

Source ID Structure
AlphaFold DB N9LW73

References