Detailed information of TA system TA182055

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 1990762..1992398
• Replicon: chromosome
• Accession: NZ_CP065051
• Organism: Acinetobacter baumannii strain 2016GDAB1

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A335SV71
• Locus tag: IVB58_RS09475
• Protein ID: WP_000737060.1
• Coordinates: 1991067..1992398 (-)
• Length: 444 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: IVB58_RS09470
• Protein ID: WP_001101310.1
• Coordinates: 1990762..1991070 (-)
• Length: 103 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IVB58_RS09455 (IVB58_09425)	1986097..1988796	+	2700	WP_000214506.1	ATP-dependent RecD-like DNA helicase	-
IVB58_RS09460 (IVB58_09430)	1988874..1989395	-	522	WP_001071843.1	hypothetical protein	-
IVB58_RS09465 (IVB58_09435)	1989477..1990037	-	561	WP_025464545.1	TetR/AcrR family transcriptional regulator	-
IVB58_RS09470 (IVB58_09440)	1990762..1991070	-	309	WP_001101310.1	helix-turn-helix domain-containing protein	Antitoxin
IVB58_RS09475 (IVB58_09445)	1991067..1992398	-	1332	WP_000737060.1	HipA domain-containing protein	Toxin
IVB58_RS09480 (IVB58_09450)	1992694..1993134	+	441	WP_000193138.1	HD domain-containing protein	-
IVB58_RS09485 (IVB58_09455)	1993170..1993814	-	645	WP_000817320.1	hypothetical protein	-
IVB58_RS09490 (IVB58_09460)	1993826..1994797	-	972	WP_094081187.1	5'/3'-nucleotidase SurE	-
IVB58_RS09495 (IVB58_09465)	1994924..1996087	-	1164	WP_001044488.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (167-359)

Antitoxin

• Cro/C1-type helix-turn-helix domain (36-83)

Sequences

Toxin

Protein

• Length: 444 a.a.
• Molecular weight: 51188.22 Da
• Isoelectric Point: 4.8490

>T182055 WP_000737060.1 NZ_CP065051:c1992398-1991067 [Acinetobacter baumannii]
MKKLTIQALLNKNWIDIAELKLLEPKLGSASASELEYELNYAIQYLDRRDEHACSLSLPVQILIKHESDTWFGFLDDIVP
SGAARRYWVNYLDLQRLTYAEQESILLEKGGMAPVGNLRIKEALPPLNPESTLHLRYFSKEDVAERNIDFLEYAQQMGAI
SGGATGAGGEAPKLLIRVSPEQKVWIDTYQEQFDQPDQHYLVKFPRNKRSEIDCDILRAEYYYYQILNELGFNTIETTQM
QLIEGTKYPSLWLPRFDTEWCDQYWHRYGLESVYSVLNKSSGSHLNHFEVIEDLCRLLTSIDSDFDVPQFVCEWLQRDLL
NIIFGNSDNHGRNTSFIKKSGKIYLSPIYDFAPMKADPEVVTRSTTWGSPYEEGGEYRWAQITQKLAPWCDPDLSLATLR
TLANNLLGLKQRLVDKGVPKQIIEMPALSFDYIEAKLKRWELL

Nucleotide

• Length: 1332 bp

>T182055 NZ_CP086292:1128365-1128733 [Burkholderia ambifaria]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCTCGAAGTACCTGAAGGACGAAGAAGCGATTCGTCACTACCTGGCGCA
AGCGTTTGAAGATGGCGATCCGCGCCTGATCCAGGCGGCGCTCGGGAACGTCGCGAAAGCGCGCGGTATGACGGCGCTGG
CGCGCGAGTCCGGCGTGAAGCGCGAAGCGCTTTACCGAGCGCTGTCGGATGGCGGGAACGCGGAGTTTGCAACGATCATG
AAGGTTGTCGGCGCGTTGGGATTGCACCTGACCGTTGCGCCGGTCGTGCAGGCGGACGAAGCGGCACCGGTGCCTGCGCC
GACACCGACGCGCGCGCGTTCGCGCGGACGTGCTGGGGTACACGCGTAA

Antitoxin

Protein

• Length: 103 a.a.
• Molecular weight: 11630.54 Da
• Isoelectric Point: 9.9701

>AT182055 WP_001101310.1 NZ_CP065051:c1991070-1990762 [Acinetobacter baumannii]
MNVKNQTQDRQQILIDLYKQYLLSEITLGQLLSYLRKNVLGLSQEQYANLVGISRRTLTDIEQDKGKLTQSVLDKVFKPL
GLKAGLVPTHEHIVSKIIKPNE

Nucleotide

• Length: 309 bp

>AT182055 NZ_CP086292:1128066-1128362 [Burkholderia ambifaria]
ATGTTCAAAGTCCTGACTACACCCCAATTTGACGAATGGCTTGAAGGGCTTCGCGACCCGGTCGGCAGCGCGGCGATTAA
CCTGCGCATCGAGCGGGCGAAGCTCGGCAACCTTGGCGAGTGGCGCGCGGTCGGTGATGGCGTCAATGAAATGAAGATCG
ACGTGGGGCCGGGATATCGGGCCTACTTCGTGCGGCGCGGAAAAATCATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACACAAAAGAAGGACATCAAGACGGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Structures

Toxin

• AlphaFold DB: A0A335SV71