182054

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1251783..1252434 Replicon chromosome
Accession NZ_CP065051
Organism Acinetobacter baumannii strain 2016GDAB1

Toxin (Protein)


Gene name hicA Uniprot ID A0A5Q0RPK1
Locus tag IVB58_RS05840 Protein ID WP_000838147.1
Coordinates 1251783..1251965 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A335N5K1
Locus tag IVB58_RS05845 Protein ID WP_000966690.1
Coordinates 1252030..1252434 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IVB58_RS05790 (IVB58_05770) 1246955..1247335 + 381 WP_000505832.1 hypothetical protein -
IVB58_RS05795 (IVB58_05775) 1247335..1247703 + 369 WP_000524219.1 hypothetical protein -
IVB58_RS05800 (IVB58_05780) 1247742..1248404 + 663 WP_001284678.1 hypothetical protein -
IVB58_RS05805 (IVB58_05785) 1248472..1248885 + 414 WP_000626004.1 hypothetical protein -
IVB58_RS05810 (IVB58_05790) 1248851..1249219 + 369 WP_001983390.1 hypothetical protein -
IVB58_RS05815 (IVB58_05795) 1249221..1249619 + 399 WP_001251842.1 phage tail terminator-like protein -
IVB58_RS05820 (IVB58_05800) 1249621..1249833 + 213 WP_001983388.1 hypothetical protein -
IVB58_RS05825 (IVB58_05805) 1249941..1250870 + 930 WP_000094301.1 phage tail tube protein -
IVB58_RS05830 (IVB58_05810) 1250918..1251451 + 534 WP_001185621.1 hypothetical protein -
IVB58_RS05835 (IVB58_05815) 1251454..1251714 + 261 WP_074163942.1 hypothetical protein -
IVB58_RS05840 (IVB58_05820) 1251783..1251965 + 183 WP_000838147.1 type II toxin-antitoxin system HicA family toxin Toxin
IVB58_RS05845 (IVB58_05825) 1252030..1252434 + 405 WP_000966690.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
IVB58_RS05850 (IVB58_05830) 1252533..1252709 + 177 WP_001983384.1 hypothetical protein -
IVB58_RS05855 (IVB58_05835) 1252718..1253041 + 324 WP_000523922.1 DUF4236 domain-containing protein -
IVB58_RS05860 (IVB58_05840) 1253075..1253608 + 534 WP_000719143.1 hypothetical protein -
IVB58_RS05865 (IVB58_05845) 1253620..1254021 + 402 WP_000758222.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1240842..1268218 27376


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6682.88 Da        Isoelectric Point: 10.6602

>T182054 WP_000838147.1 NZ_CP065051:1251783-1251965 [Acinetobacter baumannii]
VKSLDLIKMIEADGWYEVRVSGSHHHFKHPTKKGLVTIPHPKKDLPSGTVKSILKQAGLK

Download         Length: 183 bp

>T182054 NZ_CP086292:1128066-1128362 [Burkholderia ambifaria]
ATGTTCAAAGTCCTGACTACACCCCAATTTGACGAATGGCTTGAAGGGCTTCGCGACCCGGTCGGCAGCGCGGCGATTAA
CCTGCGCATCGAGCGGGCGAAGCTCGGCAACCTTGGCGAGTGGCGCGCGGTCGGTGATGGCGTCAATGAAATGAAGATCG
ACGTGGGGCCGGGATATCGGGCCTACTTCGTGCGGCGCGGAAAAATCATCGTCGTGGTGTTGTGCGGCGGGGACAAGTCG
ACACAAAAGAAGGACATCAAGACGGCGAAGCAAATCGCCGGCGAACTGGAGGATTGA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14605.61 Da        Isoelectric Point: 4.4169

>AT182054 WP_000966690.1 NZ_CP065051:1252030-1252434 [Acinetobacter baumannii]
MLYPIAIERGTDTEAFGVTVPDIPGCFSAGDTLEEAIENVKEAISGHLEILAEDGEEIPLASDLAKFVDDPDYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIRKIDENVGKGKRYTTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT182054 NZ_CP086292:1128365-1128733 [Burkholderia ambifaria]
ATGAAAATCAGCGAACTGGCCGAATTCGACGGCTCGAAGTACCTGAAGGACGAAGAAGCGATTCGTCACTACCTGGCGCA
AGCGTTTGAAGATGGCGATCCGCGCCTGATCCAGGCGGCGCTCGGGAACGTCGCGAAAGCGCGCGGTATGACGGCGCTGG
CGCGCGAGTCCGGCGTGAAGCGCGAAGCGCTTTACCGAGCGCTGTCGGATGGCGGGAACGCGGAGTTTGCAACGATCATG
AAGGTTGTCGGCGCGTTGGGATTGCACCTGACCGTTGCGCCGGTCGTGCAGGCGGACGAAGCGGCACCGGTGCCTGCGCC
GACACCGACGCGCGCGCGTTCGCGCGGACGTGCTGGGGTACACGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Q0RPK1

Antitoxin

Source ID Structure
AlphaFold DB A0A335N5K1

References