Detailed information of TA system TA182053

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): phd-doc/Fic(toxin)
• Location: 4749888..4750459
• Replicon: chromosome
• Accession: NZ_CP065050
• Organism: Streptomyces solisilvae strain HNM0141

Toxin (Protein)

• Gene name: doc
• Uniprot ID: -
• Locus tag: I1A49_RS18905
• Protein ID: WP_079257839.1
• Coordinates: 4749888..4750262 (-)
• Length: 125 a.a.

Antitoxin (Protein)

• Gene name: phd
• Uniprot ID: A0A1P8XVF0
• Locus tag: I1A49_RS18910
• Protein ID: WP_069863663.1
• Coordinates: 4750262..4750459 (-)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1A49_RS18890	4745266..4746051	-	786	WP_069863678.1	hypothetical protein	-
I1A49_RS18895	4746194..4746835	-	642	WP_069863676.1	helix-turn-helix domain-containing protein	-
I1A49_RS18900	4747980..4749776	-	1797	WP_079152962.1	DEAD/DEAH box helicase	-
I1A49_RS18905	4749888..4750262	-	375	WP_079257839.1	Fic family protein	Toxin
I1A49_RS18910	4750262..4750459	-	198	WP_069863663.1	Arc family DNA-binding protein	Antitoxin
I1A49_RS18915	4750493..4751986	-	1494	WP_206332558.1	MFS transporter	-
I1A49_RS18920	4752292..4753392	-	1101	WP_206334945.1	putative sulfate exporter family transporter	-
I1A49_RS18925	4753395..4753964	-	570	WP_079257842.1	cysteine dioxygenase family protein	-
I1A49_RS18930	4754138..4755043	-	906	WP_069863657.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (11-80)

Antitoxin

• Arc-like DNA binding domain (4-42)

Sequences

Toxin

Protein

• Length: 125 a.a.
• Molecular weight: 14001.81 Da
• Isoelectric Point: 4.7465

>T182053 WP_079257839.1 NZ_CP065050:c4750262-4749888 [Streptomyces solisilvae]
MHYLTLPELLNLAERLGESEVRDYGLLESALARPQASVFGQDAYPDVWQKAAALMESSARNHALVDGNKRLSWYATWVFL
HINGHPLHADFDVDEAERFVLSVCQGELDVAKIAEGLTRFTERM

Nucleotide

• Length: 375 bp

>T182053 NZ_CP086292:747842-748249 [Burkholderia ambifaria]
ATGAAGTTTCTGCTGGATACCAACGCGGTAATCGCGATTCTGAAAGGCGAACAGGCCATGCTGGCCCGATTGCGTAGCCA
TCAACCTGCGGATTTCGGAATTCCCGCGATCGTCGCGCATGAACTCTATTACGGGGCGTACAAGAGTCAGAGAGCGGCAG
CGAATCTGGCACGCGTCGAGGGGCTTCAGTTCGAGGTCGTGTCGTTCGATGCGGAAGATGCGCAGCATGCCGGTGAAATC
CGTGCGCAACTGGCCGCGGTGGGAACACCGATCGGGCCATACGATGCATTGATCGCAGGACAGGCGCGAGCGCGACGCCT
GGTGCTTGTCACGCACAACACGCGCGAGTTTGAGCGGATCTCGGAGCTGCAGGTCGAGGATTGGCTCGCGGCGGCGCGCG
AAAAGTGA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7439.31 Da
• Isoelectric Point: 5.6033

>AT182053 WP_069863663.1 NZ_CP065050:c4750459-4750262 [Streptomyces solisilvae]
MAALNLRFTDEELDALRKRAEAEGRSMQSFAHDAVMAAINEHSRRFDEAADHVLRVSEELNRRLA

Nucleotide

• Length: 198 bp

>AT182053 NZ_CP086292:747603-747845 [Burkholderia ambifaria]
ATGGAGACTGCCAAGATTTTCAAGCATGGTGGATCGCAGGCCGTCCGCTTGCCGAAGGATTTCCGCTTCGATACAACGGA
GGTCCGGATTCGTCGGCACGGCGCGTCTGTCATTCTCGAGCCGGTGCCGCAAGACTGGGCATGGCTGACACCGTTGATCG
GTCCGGTTGACGCCGATTTCGAGGCCGCCGCAGCAACCGAGCCTGCCGCTCAAGAGCGTCCAGGGCTGGACGTGTTTGAA
TGA

Structures

Antitoxin

• AlphaFold DB: A0A1P8XVF0