Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Rv0298-Rv0299/-
Location 5261639..5262168 Replicon chromosome
Accession NZ_CP065047
Organism Mycobacterium kubicae strain JCM 13573

Toxin (Protein)


Gene name Rv0299 Uniprot ID X7VD93
Locus tag I2456_RS24540 Protein ID WP_007172144.1
Coordinates 5261863..5262168 (+) Length 102 a.a.

Antitoxin (Protein)


Gene name Rv0298 Uniprot ID D5P1N8
Locus tag I2456_RS24535 Protein ID WP_007172145.1
Coordinates 5261639..5261866 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2456_RS24520 5257207..5258544 - 1338 WP_139823271.1 DUF87 domain-containing protein -
I2456_RS24525 5258534..5259589 - 1056 WP_007172148.1 hypothetical protein -
I2456_RS24530 5259663..5261153 - 1491 WP_007172147.1 type VII secretion protein EccB -
I2456_RS24535 5261639..5261866 + 228 WP_007172145.1 ribbon-helix-helix protein, CopG family Antitoxin
I2456_RS24540 5261863..5262168 + 306 WP_007172144.1 hypothetical protein Toxin
I2456_RS24545 5262540..5263475 - 936 WP_109413176.1 hypothetical protein -
I2456_RS24550 5264913..5265200 - 288 WP_007172141.1 hypothetical protein -
I2456_RS24555 5265488..5265820 - 333 WP_033717256.1 hypothetical protein -
I2456_RS24560 5265820..5266497 - 678 WP_101930854.1 hypothetical protein -
I2456_RS24565 5266567..5266953 - 387 WP_007172138.1 YbaB/EbfC family nucleoid-associated protein -
I2456_RS24570 5266950..5267090 - 141 WP_007172137.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4891286..5274661 383375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Ribbon-helix-helix protein, CopG

(6-41)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 10428.23 Da        Isoelectric Point: 3.9382

>T182052 WP_007172144.1 NZ_CP065047:5261863-5262168 [Mycobacterium kubicae]
VITPGDITPGRDTNQELYVVVLSNTIHLAAATGQVIICPFIPGEIPSSTMAMIVTVLQPKGVVLPELIQWLPVAALDQPI
GNIGGIALADTTTTAVTALIS

Download         Length: 306 bp

>T182052 NZ_CP086292:594102-594521 [Burkholderia ambifaria]
ATGATCCTCGTCGATACCAACGTCATTTCCGAGCCGCTGCGGCGCGAGCCGAGTGCGGCCGTGATCGAATGGCTCGATGC
GCAGAATGTCGAGACGCTGTTTCTTGCCGCGATCAGTCTCGCGGAAATGCGTTTCGGCGTGGCCGCGTTGCCGGAAGGGA
GAAGGCGGGACTGGCTGCACCAAAGCATCGAGCAGCGCGTCGTGCCGCTGTTTCGCGGCCGGATCCTGCCGTTCGACGAC
GCGGCCAGTAAAGCCTATGCGAGCCTTCGCGCGAAGGCTCGCGCCACGGGCAACGCGATGGCGTCTGCCGATGGATTTAT
CGCTGCCACGGCCGCCGCGAACGGCTTGATCGTGGCGACGCGTGATGTCGCGCCGTTCGAAGCGGCGGGCTTGCGCGTGA
TCGATCCGTGGGCCGGGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8153.21 Da        Isoelectric Point: 5.0079

>AT182052 WP_007172145.1 NZ_CP065047:5261639-5261866 [Mycobacterium kubicae]
MAKAKVSVMIEEAVLAAADADAQAAGLNRSEMIERALHNEHLRISLENYTTHTVPTLDIDAYAEKVYQANRAAGL

Download         Length: 228 bp

>AT182052 NZ_CP086292:593866-594105 [Burkholderia ambifaria]
ATGCCGGTTATTACCGTTCGAAATTTGCCCGACGAGGTGCATCGCGCGCTTCGCATCCGTGCGGCGCAACATGGTCGGAG
TACCGAAGCGGAGGTGCGCGCCATCCTCGAGGAGGCCGTTCGGCCCGGCGGGCGGACGAAGCTGGGGTCGCTGCTGGCCG
AAATCGGGCGGGAGGCGGGCGGTGTCGATTTCGAGAATCCGCGCGAGAGCTCGCCAACCGCTCCGATGAGCTTCGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XDZ0

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XDJ0

References