Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN-PHD
Location 5025638..5026305 Replicon chromosome
Accession NZ_CP065047
Organism Mycobacterium kubicae strain JCM 13573

Toxin (Protein)


Gene name vapC Uniprot ID D5PE24
Locus tag I2456_RS23505 Protein ID WP_007168407.1
Coordinates 5025638..5026030 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID D5PE23
Locus tag I2456_RS23510 Protein ID WP_007168406.1
Coordinates 5026030..5026305 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2456_RS23485 5020897..5022231 - 1335 Protein_4657 IS1182 family transposase -
I2456_RS23490 5022568..5022690 + 123 Protein_4658 IS1595 family transposase -
I2456_RS23495 5022951..5024289 + 1339 Protein_4659 DUF1298 domain-containing protein -
I2456_RS23500 5024331..5025490 + 1160 Protein_4660 trehalose-phosphatase -
I2456_RS23505 5025638..5026030 - 393 WP_007168407.1 type II toxin-antitoxin system VapC family toxin Toxin
I2456_RS23510 5026030..5026305 - 276 WP_007168406.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I2456_RS23515 5026458..5027330 - 873 WP_007168405.1 MaoC family dehydratase N-terminal domain-containing protein -
I2456_RS23520 5027413..5028116 + 704 Protein_4664 histidine phosphatase family protein -
I2456_RS23525 5028169..5028258 + 90 Protein_4665 SDR family oxidoreductase -
I2456_RS23530 5028252..5028884 + 633 Protein_4666 DDE-type integrase/transposase/recombinase -
I2456_RS23535 5029071..5030246 + 1176 Protein_4667 ISL3 family transposase -
I2456_RS23540 5030252..5030485 + 234 Protein_4668 transposase -
I2456_RS23545 5030475..5030801 + 327 WP_033711234.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 4891286..5274661 383375


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-45)


Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14305.73 Da        Isoelectric Point: 10.5032

>T182051 WP_007168407.1 NZ_CP065047:c5026030-5025638 [Mycobacterium kubicae]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRLPRVSSALARTEVMRALLHKGESARRAGRRALASLDLLRIDNRLLDLAG
GLLPIELRTLDAIHLATAQRLGMDLGRLCTYDDRMRDAAEALGMAVIAPS

Download         Length: 393 bp

>T182051 NZ_CP086292:c348417-347836 [Burkholderia ambifaria]
ATGAACCTCGACACGATCCACGCGCGGCTCGATTTCCTGCGCGAAGCCGAACGCCTGAAAGACGTGCTGCGCAGCGGCCA
CACGTCGACGGGCCGCCGCGAAAGCACGGCCGAGCACAGCTGGCGCCTCTGCCTGATGGCGCTCGTGTTCGCCGATGCGC
TGCCCGACGTCGACACGACGAAGCTGCTGAAACTGTGCGTCGTCCACGATCTCGGCGAAGCGCTGCACGGCGACATCCCC
GCGATCGAGCAGGCCGCGCATCCGGACAAGAGCACGCACGAACGCGACGACCTGCTGACGCTGACGGCCGGCCTCGATCG
CGCGCTGCGCGACGAGATCGTCGCGCTGTGGGATGAATACGAGGCGGCCGAATCGCCGGAAGCGCGCGCCGCGAAGGCGC
TCGACAAGCTGGAGACGATCCTGCAGCACAACCAGGGCAGCAATCCGCCCGACTTCGACTACGCGTTCAATCTCGCCTAC
GGGCGGCGCTACACCGACGCGACGCCGCTGTTCGACGCGATCCGCGCGATCGTCGACGCGGACACGCAACGCCGGATCGA
CGCACGCGGCGACGACGCGTAA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10150.63 Da        Isoelectric Point: 5.1881

>AT182051 WP_007168406.1 NZ_CP065047:c5026305-5026030 [Mycobacterium kubicae]
MSTVGVRELRQRASELLRRVEAGETIEITDRGRPIALLSPMPEGGPYQQMLASGGIERATLDFDDLPEPVRLKTGIELPS
VTLARLREHER

Download         Length: 276 bp

>AT182051 NZ_CP086292:c349083-348526 [Burkholderia ambifaria]
ATGACGACCTCGCCGCTTCACACCCCGCCGCTCGGCCCGCAACTCAAGCGCTGGCGCACGCTGCGCCGCGTGAAGCAGAG
CCATGCGGCCGAGCTGTTCGGCGTCGCGCAATCGACGATCTCGCGCTGGGAAGCCGGCATCCAGCAGATGTCGCCCGACG
AGCGCGCGACGGCCGAGCGGCTGCTTGCCGCGCGTCTCGACTCGGCCGGCGACCACGCGCTCGCGCGGCTGATCGCGAGC
AGCACGGCCCGCATGCATCTCGTGTGCGACCTCACGCATCGGCTGCTCGCCTGCTCGCCGTCGCGCGCGGCCGAGTTCTC
TCGGCCGCTGCCGGCGTTGCTCGGTACCTCGCTGTGGCGCTATGCGTCGCCGGAAATCGTCCGCATGGAAGCCGCGCTCG
ACCCGCTCGGCTGGCACGATCGCGCGGGGCCGCCGAGCGTCGAATTCGCGACCGGCACCAATGCGTCGCGCGTCGTGCCG
ATCCGCGGCGGCACCTGCCGGTGGACGCGAATGACACTGTCGGACGGCTCCGCCGCGCGGCTCGTCGAAACGCTGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X1XV84

Antitoxin

Source ID Structure
AlphaFold DB A0A1X1XUZ3

References