Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 4855303..4855838 Replicon chromosome
Accession NZ_CP065044
Organism Pectobacterium aroidearum strain L6

Toxin (Protein)


Gene name relE Uniprot ID A0A7V8Q6Q4
Locus tag I2D83_RS21685 Protein ID WP_039284929.1
Coordinates 4855551..4855838 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q6DB37
Locus tag I2D83_RS21680 Protein ID WP_010281712.1
Coordinates 4855303..4855554 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2D83_RS21655 4850598..4851731 + 1134 WP_205947286.1 alkylhydroperoxidase domain protein -
I2D83_RS21660 4851774..4852397 - 624 WP_194431385.1 LysE family translocator -
I2D83_RS21665 4852579..4853283 + 705 WP_205947287.1 SMI1/KNR4 family protein -
I2D83_RS21670 4853353..4854108 + 756 WP_205947288.1 thiol:disulfide interchange protein DsbG -
I2D83_RS21675 4854143..4855048 - 906 WP_205947289.1 siderophore-interacting protein -
I2D83_RS21680 4855303..4855554 + 252 WP_010281712.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I2D83_RS21685 4855551..4855838 + 288 WP_039284929.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I2D83_RS21690 4855946..4857298 - 1353 WP_181848045.1 glutathione-disulfide reductase -
I2D83_RS21695 4857427..4858269 - 843 WP_015842271.1 23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ -
I2D83_RS21700 4858623..4859351 + 729 WP_043881851.1 DUF1266 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11088.18 Da        Isoelectric Point: 10.3527

>T182047 WP_039284929.1 NZ_CP065044:4855551-4855838 [Pectobacterium aroidearum]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDILIIAVVAVGK
RERSGVYHLASERMR

Download         Length: 288 bp

>T182047 NZ_CP086287:c4897808-4897434 [Citrobacter freundii]
ATGGTCAAAGGATCCGCGCTTTTTGATACCAACATCCTCATCGATCTGTTTAGTGGGAGAAATGAAGCAAAACTAGCGAT
AGAAACATGGCCGCCGCAGAATGCAATCAGCCTCATTACATGGATGGAGGTGATGGTGGGTGCAAAAAAATACCATCAGG
AAGCCCGTACTCGTGTTGCGCTAGGTGCTTTTAACGTGATCGGCGTTTCACAGGATATTGCTGAACGAAGCGTGAGTATC
AGACAGGAATATGGGATGAAATTGCCGGATGCCATTATTTTGGCAACAGCACAGATTCATCGTCTTACGCTGGTTACGCG
AAATACTAAGGATTTTGCAGGCCTATCCGGTGTGGTCACACCGTATACATTATAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9117.47 Da        Isoelectric Point: 4.0637

>AT182047 WP_010281712.1 NZ_CP065044:4855303-4855554 [Pectobacterium aroidearum]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Download         Length: 252 bp

>AT182047 NZ_CP086287:c4898050-4897808 [Citrobacter freundii]
ATGATGGCTGGGATGGATATGGGCAGAATTTTACTCGATTTATCAGATGAAGTGATTAAACGTCTTGATGATCTCAAGGT
GCAGCGCAACCTGCCGCGAGCAGAACTTTTACGGGAGGCCGTTGAACAGTATCTTGAGAGACAGGATCAGGCTGAAACCA
CAATTTCACGTGCTCTTGGGCTGTGGCAAGGCTGTGAGGAAGATGGTGTTGAATACCAGCGTAAACTCCGTGAGGAATGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7V8Q6Q4

Antitoxin

Source ID Structure
AlphaFold DB A0A0M2EZP0

References