Detailed information of TA system TA182046

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-DnaT
• Location: 4555495..4556026
• Replicon: chromosome
• Accession: NZ_CP065044
• Organism: Pectobacterium aroidearum strain L6

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: A0A1V2R9S3
• Locus tag: I2D83_RS20305
• Protein ID: WP_012822123.1
• Coordinates: 4555495..4555782 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: -
• Locus tag: I2D83_RS20310
• Protein ID: WP_180778477.1
• Coordinates: 4555772..4556026 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2D83_RS20280	4550667..4550822	+	156	WP_012773032.1	hypothetical protein	-
I2D83_RS20285	4550957..4552348	+	1392	WP_205947214.1	outer membrane channel protein TolC	-
I2D83_RS20290	4552615..4553289	+	675	WP_012773030.1	DUF1190 family protein	-
I2D83_RS20295	4553301..4554461	+	1161	WP_180778474.1	glutathionylspermidine synthase family protein	-
I2D83_RS20300	4554531..4555316	-	786	WP_012773028.1	4,5-DOPA dioxygenase extradiol	-
I2D83_RS20305	4555495..4555782	-	288	WP_012822123.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
I2D83_RS20310	4555772..4556026	-	255	WP_180778477.1	plasmid stabilization protein	Antitoxin
I2D83_RS20320	4556917..4557804	-	888	WP_205947215.1	16S rRNA (cytidine(1402)-2'-O)-methyltransferase	-
I2D83_RS20325	4557866..4559884	+	2019	WP_181829974.1	penicillin-binding protein activator	-
I2D83_RS20330	4559842..4560237	+	396	WP_181830009.1	YraN family protein	-
I2D83_RS20335	4560301..4560891	+	591	WP_012773024.1	DnaA initiator-associating protein DiaA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10997.94 Da
• Isoelectric Point: 10.7694

>T182046 WP_012822123.1 NZ_CP065044:c4555782-4555495 [Pectobacterium aroidearum]
MTYKLKFVPSAMKEWKKLGHPVREQFKKKLVERLENPRVPSAQLHGRKDQYKIKLKSAGYRLVYLVQDETITVMVMGVGK
REGSQVYSDTKGRSA

Nucleotide

• Length: 288 bp

>T182046 NZ_CP086287:c4746166-4745807 [Citrobacter freundii]
ATGACGAAACCACTTTACTGGGTTGGGCAGGCCAGAAAAGACCTGATTGCAATGCCAGAACACGTTCGGGATACGTTTGG
GTTTGCTCTTTGGCTTGCGCAACAGGGTAAACAGCATTCACAGACTAAACCATTAAAAGGATTTGGTGGAGCGGGGGTTC
TGGAAGTCGTTGAGGATTATCACGGCAACGCCTGGCGGGCGGTTTACACCATCCAGTTGAAAAATGCGGTTTATGTTCTC
CATGTTTTTCAGAAGAAGTCCGTTTCCGGGAAAGCAACCCCGAAACCTGAAATTGACCTGATTTATCAGCGGCTCAAGGC
TGCACAGCGCCATGCGCAGGAGAGTGGATATGTCACATGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9240.44 Da
• Isoelectric Point: 3.7947

>AT182046 WP_180778477.1 NZ_CP065044:c4556026-4555772 [Pectobacterium aroidearum]
MAFNILTNTAASITELKRDPMGTVRAAEGETIAILNRNEPAFYCVPPAMFAYLMELAEDAELGRTVDDRMSELADAEEIS
LDDL

Nucleotide

• Length: 255 bp

>AT182046 NZ_CP086287:c4745817-4745500 [Citrobacter freundii]
ATGTCACATGATGTCGAAACCAGTAGCGGTAATGTTTACGCCGATTTAGGTGCGTATGACGCAGAACAGATGCAGTTGAA
AGCGCAGCTGGCAATGGTGATTGGTGAGATTTTGCAACGCAAAGGGTTAACGCAGCAGCAGGCCGCGCAGTTACTGGGAA
TGACACAGCCTAAACTTTCCAATCTGCTACGCGGCCAGTTTCGCGGTATCAGTGAAGCAAAGATGCTCGAATGCCTGGTG
AGGCTGGGCCGTGATGTAGAGATTGTTGTCGGGAAAGAGGGCAATATGTCAGGAAAGCTGAAAGTGAAATTTGGCTGA

Structures

Toxin

• AlphaFold DB: A0A1V2R9S3