Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4145536..4146196 Replicon chromosome
Accession NZ_CP065044
Organism Pectobacterium aroidearum strain L6

Toxin (Protein)


Gene name cptA Uniprot ID A0A7W2E4X8
Locus tag I2D83_RS18465 Protein ID WP_012773341.1
Coordinates 4145536..4145949 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID C6D8Y5
Locus tag I2D83_RS18470 Protein ID WP_012773340.1
Coordinates 4145930..4146196 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2D83_RS18440 4140913..4141812 - 900 WP_012773347.1 site-specific tyrosine recombinase XerD -
I2D83_RS18445 4142124..4143452 + 1329 WP_012773346.1 MHS family MFS transporter -
I2D83_RS18450 4143615..4144133 + 519 WP_012773344.1 flavodoxin FldB -
I2D83_RS18455 4144162..4144485 + 324 WP_180777498.1 hypothetical protein -
I2D83_RS18460 4144531..4145466 - 936 WP_205947072.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
I2D83_RS18465 4145536..4145949 - 414 WP_012773341.1 protein YgfX Toxin
I2D83_RS18470 4145930..4146196 - 267 WP_012773340.1 FAD assembly factor SdhE Antitoxin
I2D83_RS18475 4146432..4147433 + 1002 WP_205947073.1 tRNA-modifying protein YgfZ -
I2D83_RS18480 4147488..4148135 - 648 WP_012773338.1 hemolysin III family protein -
I2D83_RS18485 4148548..4149156 + 609 WP_181829659.1 HD domain-containing protein -
I2D83_RS18490 4149200..4150204 + 1005 WP_205947074.1 LacI family DNA-binding transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16302.21 Da        Isoelectric Point: 10.6525

>T182042 WP_012773341.1 NZ_CP065044:c4145949-4145536 [Pectobacterium aroidearum]
VAQWQCDLRVSWRMQLLSLIVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGEIVLLSETTLNWRQQ
EWQIVKRPWLLKNGVLLSLQAVNGKDRQQLWLASDSMGDDEWRHLRQLLLQQKNWAR

Download         Length: 414 bp

>T182042 NZ_CP086287:2200562-2200665 [Citrobacter freundii]
GGCAGGGTAACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10465.94 Da        Isoelectric Point: 6.2223

>AT182042 WP_012773340.1 NZ_CP065044:c4146196-4145930 [Pectobacterium aroidearum]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLSDSDKRTFVRLLQSDDPDLFNWLMNHGEPKDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT182042 NZ_CP086287:c2200670-2200527 [Citrobacter freundii]
CACATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTT
GGCATTAATGCAGGCTAAGTTACCCTGCCATTTAAGAATAGATGACAGCGCCAGGTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7W2E4X8

Antitoxin

Source ID Structure
AlphaFold DB A0A7W2E501

References