Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3716517..3717142 Replicon chromosome
Accession NZ_CP065044
Organism Pectobacterium aroidearum strain L6

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag I2D83_RS16635 Protein ID WP_005976087.1
Coordinates 3716939..3717142 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag I2D83_RS16630 Protein ID WP_005976089.1
Coordinates 3716517..3716885 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I2D83_RS16615 3712148..3715276 + 3129 WP_015839362.1 multidrug efflux RND transporter permease subunit -
I2D83_RS16620 3715511..3715759 + 249 WP_015839361.1 type B 50S ribosomal protein L31 -
I2D83_RS16625 3715777..3715920 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
I2D83_RS16630 3716517..3716885 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
I2D83_RS16635 3716939..3717142 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
I2D83_RS16645 3717889..3718209 + 321 WP_015839360.1 MGMT family protein -
I2D83_RS16650 3718229..3718810 - 582 WP_015839359.1 YbaY family lipoprotein -
I2D83_RS16655 3719022..3719885 + 864 WP_015839358.1 acyl-CoA thioesterase II -
I2D83_RS16660 3720038..3721324 - 1287 WP_015839357.1 ammonium transporter AmtB -
I2D83_RS16665 3721362..3721700 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T182040 WP_005976087.1 NZ_CP065044:3716939-3717142 [Pectobacterium aroidearum]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T182040 NZ_CP086287:c368425-368108 [Citrobacter freundii]
ATGTTCACATTTATTGAGCTACAAGGATTTAGTAAACGCCGTCCGTTACTTTTGCCTGACGATGAGTTTCGCGCTTTTCA
AGAGGCGCTTATAGAGAACCCTGAGGCTGGAGATACTATCGCTGGTACAGGTGGATTCAGAAAAATTCGCTGGAGTCGCT
CTGGTATGGGCAAACGCAGCGGTATTAGGGTTATCTATTACAACGTGACGCGCAAAGGTCGAATCTATCTCGCTTTGCTC
TATCCTAAAAATGAACAGGATGATTTAACCGAAGAGCAAAAAAGAGTTTTAATGCACTTATCCAATATGCTGATTTAA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT182040 WP_005976089.1 NZ_CP065044:3716517-3716885 [Pectobacterium aroidearum]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT182040 NZ_CP086287:c368055-367759 [Citrobacter freundii]
ATGAAAGACGAATTATTTGCCGATTTGCTGGCCAGTGCAGAAGAAATGGTGCGTATAGAGAAAGGTGAAGAAACACCTAA
GCCTGAACATGTACATACCTTTAGCGAAATTGATGTTAAAGCCATCCGCGAAGCAACAGGGTTACGCCAACAGGATTTTG
CCATAGCTGTTGGCGTGAGTTATGACCTGGTTAAAAGCTGGGAAACGAAACGACGCCAGCCGACTGGTGCACCAAGAAAA
CTGCTTTTATTAATTCAAAAAAATCCATTTATAATTAATCAATTAAAAGCAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References