Detailed information of TA system TA182037

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hicAB/HicA-HicB
• Location: 217123..217740
• Replicon: chromosome
• Accession: NZ_CP065044
• Organism: Pectobacterium aroidearum strain L6

Toxin (Protein)

• Gene name: hicA
• Uniprot ID: C6DHN3
• Locus tag: I2D83_RS00915
• Protein ID: WP_010281507.1
• Coordinates: 217561..217740 (-)
• Length: 60 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: I2D83_RS00910
• Protein ID: WP_180779155.1
• Coordinates: 217123..217533 (-)
• Length: 137 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I2D83_RS00895	212948..213991	-	1044	WP_012772905.1	DNA-binding transcriptional regulator CytR	-
I2D83_RS00900	214268..216466	-	2199	WP_181847420.1	primosomal protein N'	-
I2D83_RS00905	216781..216996	+	216	WP_012772907.1	50S ribosomal protein L31	-
I2D83_RS00910	217123..217533	-	411	WP_180779155.1	type II toxin-antitoxin system HicB family antitoxin	Antitoxin
I2D83_RS00915	217561..217740	-	180	WP_010281507.1	type II toxin-antitoxin system HicA family toxin	Toxin
I2D83_RS00920	217838..218848	-	1011	WP_205947382.1	iron ABC transporter permease	-
I2D83_RS00925	218845..219807	-	963	WP_205947383.1	ABC transporter substrate-binding protein	-
I2D83_RS00930	219817..220614	-	798	WP_205947384.1	ABC transporter ATP-binding protein	-
I2D83_RS00935	220830..221147	-	318	WP_005973355.1	met regulon transcriptional regulator MetJ	-
I2D83_RS00940	221335..222495	+	1161	WP_012772912.1	cystathionine gamma-synthase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HicA mRNA interferase family (4-59)

Antitoxin

• HicB-like antitoxin of toxin-antitoxin system (3-128)

Sequences

Toxin

Protein

• Length: 60 a.a.
• Molecular weight: 6560.69 Da
• Isoelectric Point: 10.7838

>T182037 WP_010281507.1 NZ_CP065044:c217740-217561 [Pectobacterium aroidearum]
MDSRTLIAEIKADGWELIRVNGSHHHFMHPSKPGLVTIPHPKKDLPIGTVKSIRKQAGI

Nucleotide

• Length: 180 bp

>T182037 NZ_CP086285:c5148885-5148502 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin

Protein

• Length: 137 a.a.
• Molecular weight: 14492.36 Da
• Isoelectric Point: 4.3391

>AT182037 WP_180779155.1 NZ_CP065044:c217533-217123 [Pectobacterium aroidearum]
MFYPIAIEAGDDTHAYGVTVPDLPGCFSAGDTLDDAIANAKEAITGHIELLVEMGQDIPTVSTVGQLAKGSEYAGYTWAV
VDIDVTRLMGGSEKINVTLPKSLIDRIDRCVASNPEFKSRSGFLAQAALERISSSR

Nucleotide

• Length: 411 bp

>AT182037 NZ_CP086285:c5149127-5148885 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Structures

Toxin

• AlphaFold DB: A0A7W2I1S0