Detailed information of TA system TA182033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 950843..951392
• Replicon: chromosome
• Accession: NZ_CP065042
• Organism: Photobacterium damselae subsp. damselae strain AS-16-0963-3

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: IPQ37_RS18930
• Protein ID: WP_106224316.1
• Coordinates: 950843..951142 (-)
• Length: 100 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: IPQ37_RS18935
• Protein ID: WP_237043000.1
• Coordinates: 951150..951392 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IPQ37_RS18905 (IPQ37_18900)	947275..948966	+	1692	WP_106224313.1	galactosyl transferase	-
IPQ37_RS18910 (IPQ37_18905)	949085..949624	+	540	WP_005304240.1	NUDIX hydrolase	-
IPQ37_RS18915 (IPQ37_18910)	949628..949843	+	216	WP_036765410.1	DUF3820 family protein	-
IPQ37_RS18920 (IPQ37_18915)	949854..950342	+	489	WP_086368229.1	leucine-rich repeat domain-containing protein	-
IPQ37_RS18925 (IPQ37_18920)	950417..950797	-	381	WP_237042999.1	hypothetical protein	-
IPQ37_RS18930 (IPQ37_18925)	950843..951142	-	300	WP_106224316.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IPQ37_RS18935 (IPQ37_18930)	951150..951392	-	243	WP_237043000.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IPQ37_RS18940 (IPQ37_18935)	951538..952833	-	1296	WP_237043001.1	DEAD/DEAH box helicase	-
IPQ37_RS18945 (IPQ37_18940)	953009..953431	-	423	WP_005304250.1	DUF3010 family protein	-
IPQ37_RS18950 (IPQ37_18945)	953606..953956	-	351	WP_005304253.1	hypothetical protein	-
IPQ37_RS18955 (IPQ37_18950)	954027..954533	-	507	WP_044179650.1	M48 family metallopeptidase	-
IPQ37_RS18960 (IPQ37_18955)	954640..955092	+	453	WP_106141840.1	isoprenylcysteine carboxylmethyltransferase family protein	-
IPQ37_RS18965 (IPQ37_18960)	955163..955696	+	534	WP_005304256.1	molybdopterin adenylyltransferase	-
IPQ37_RS18970 (IPQ37_18965)	955819..956283	-	465	WP_036765423.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-93)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-48)

Sequences

Toxin

Protein

• Length: 100 a.a.
• Molecular weight: 11488.21 Da
• Isoelectric Point: 9.3232

>T182033 WP_106224316.1 NZ_CP065042:c951142-950843 [Photobacterium damselae subsp. damselae]
MYKSRYKLSQLAQSHLRKIKSYTTENFSELQWSNYKAILISGFQMLADNPDLGKHCADIYPNGFYFPIGKHTVFFTKEDD
FILVVAVLGQTQLPQNHLK

Nucleotide

• Length: 300 bp

>T182033 NZ_CP086285:3925342-3925560 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACCTCTGTCTGGAAATTTATCCGCTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9001.24 Da
• Isoelectric Point: 6.4589

>AT182033 WP_237043000.1 NZ_CP065042:c951392-951150 [Photobacterium damselae subsp. damselae]
MRTLSANDAKRHFGELLLNAQRGPVKISKNRKDAVVVMSIQDFEELETMKVEYLTHCFKSAKEDLNNGTAVDGESFLNSL

Nucleotide

• Length: 243 bp

>AT182033 NZ_CP086285:3924941-3925315 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG