182028

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 534383..535019 Replicon chromosome
Accession NZ_CP065040
Organism Bacillus altitudinis strain Ba1449

Toxin (Protein)


Gene name mazF Uniprot ID K2MHT4
Locus tag I1A55_RS02585 Protein ID WP_003214169.1
Coordinates 534669..535019 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID W8QJ31
Locus tag I1A55_RS02580 Protein ID WP_003214273.1
Coordinates 534383..534664 (+) Length 94 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A55_RS02560 530537..531142 - 606 WP_007496491.1 rhomboid family intramembrane serine protease -
I1A55_RS02565 531237..531602 + 366 WP_017366663.1 holo-ACP synthase -
I1A55_RS02570 531763..532779 + 1017 WP_007496489.1 outer membrane lipoprotein-sorting protein -
I1A55_RS02575 532908..534089 + 1182 WP_206114209.1 alanine racemase -
I1A55_RS02580 534383..534664 + 282 WP_003214273.1 hypothetical protein Antitoxin
I1A55_RS02585 534669..535019 + 351 WP_003214169.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
I1A55_RS02590 535134..535964 + 831 WP_007496484.1 STAS domain-containing protein -
I1A55_RS02595 535969..536337 + 369 WP_003214235.1 RsbT antagonist protein RsbS -
I1A55_RS02600 536340..536741 + 402 WP_003214085.1 anti-sigma regulatory factor -
I1A55_RS02605 536752..537759 + 1008 WP_008346904.1 PP2C family protein-serine/threonine phosphatase -
I1A55_RS02610 537819..538148 + 330 WP_008346902.1 anti-sigma factor antagonist -
I1A55_RS02615 538145..538633 + 489 WP_007496471.1 anti-sigma B factor RsbW -
I1A55_RS02620 538599..539387 + 789 WP_012009000.1 RNA polymerase sigma factor SigB -
I1A55_RS02625 539387..539986 + 600 WP_008346897.1 SpoIIE family protein phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12976.99 Da        Isoelectric Point: 5.1663

>T182028 WP_003214169.1 NZ_CP065040:534669-535019 [Bacillus altitudinis]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEINAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMEKVDEALQVSLALIDF

Download         Length: 351 bp

>T182028 NZ_CP086285:324462-324830 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGCATGACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGCGGATGA

Antitoxin


Download         Length: 94 a.a.        Molecular weight: 10864.25 Da        Isoelectric Point: 5.2726

>AT182028 WP_003214273.1 NZ_CP065040:534383-534664 [Bacillus altitudinis]
MSESSATNEMKIRLPEALMSEIERVAEQDKVTRNELIYRATKTYIRERNIRQNRESMRRGYMEMAKINLNISSEAQYAEF
EAENTVERLVSGG

Download         Length: 282 bp

>AT182028 NZ_CP086285:324244-324465 [Klebsiella pneumoniae]
ATGAGAACGGTTAACTATAGCGAAGCCCGGCAAAATCTGGCCGATGTGCTGGAAAGCGCAGTGACAGGTGTACCTGTGAC
CATTACCCGTCGTGGGCATAAATCTGCAGTCATCATTAGTGCAGAAGAGTTTGAACGCTACCAGGCGGCCAGAATGGATG
ATGAGTTCGCGGCTATCATGGCGGTTCATGGTGATGAGATCAGGGAGCTTGCGGATAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K2MHT4

Antitoxin

Source ID Structure
AlphaFold DB A0A081L854

References