Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hicAB/HicA-HicB |
| Location | 4106898..4107543 | Replicon | chromosome |
| Accession | NZ_CP065039 | ||
| Organism | Proteus mirabilis strain XH1653 | ||
Toxin (Protein)
| Gene name | hicA | Uniprot ID | B4ET86 |
| Locus tag | I1A52_RS19235 | Protein ID | WP_004247035.1 |
| Coordinates | 4106898..4107083 (+) | Length | 62 a.a. |
Antitoxin (Protein)
| Gene name | hicB | Uniprot ID | B4ET85 |
| Locus tag | I1A52_RS19240 | Protein ID | WP_004247034.1 |
| Coordinates | 4107130..4107543 (+) | Length | 138 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I1A52_RS19190 (I1A52_19135) | 4102126..4102353 | + | 228 | WP_004247042.1 | YejL family protein | - |
| I1A52_RS19195 (I1A52_19140) | 4102377..4104110 | + | 1734 | WP_012367752.1 | LPS biosynthesis-modulating metalloenzyme YejM | - |
| I1A52_RS19205 (I1A52_19150) | 4104528..4104803 | + | 276 | WP_049208653.1 | hypothetical protein | - |
| I1A52_RS19210 (I1A52_19155) | 4104907..4105458 | + | 552 | WP_049208654.1 | PH domain-containing protein | - |
| I1A52_RS19215 (I1A52_19160) | 4105571..4105723 | - | 153 | WP_155289810.1 | hypothetical protein | - |
| I1A52_RS19220 | 4105784..4105987 | - | 204 | Protein_3731 | hypothetical protein | - |
| I1A52_RS19225 | 4106014..4106382 | - | 369 | WP_223232026.1 | DUF1073 domain-containing protein | - |
| I1A52_RS19230 | 4106325..4106810 | - | 486 | WP_223231960.1 | DUF1073 domain-containing protein | - |
| I1A52_RS19235 (I1A52_19170) | 4106898..4107083 | + | 186 | WP_004247035.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
| I1A52_RS19240 (I1A52_19175) | 4107130..4107543 | + | 414 | WP_004247034.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
| I1A52_RS19245 (I1A52_19180) | 4107639..4108280 | + | 642 | WP_065424673.1 | response regulator | - |
| I1A52_RS19250 (I1A52_19185) | 4108505..4108747 | + | 243 | WP_228766819.1 | hypothetical protein | - |
| I1A52_RS19255 (I1A52_19190) | 4108860..4109438 | - | 579 | WP_004247796.1 | alpha/beta hydrolase | - |
| I1A52_RS19260 (I1A52_19195) | 4110289..4111035 | + | 747 | Protein_3739 | class I SAM-dependent methyltransferase | - |
| I1A52_RS19265 (I1A52_19200) | 4111212..4111388 | - | 177 | WP_185966348.1 | hypothetical protein | - |
| I1A52_RS19270 (I1A52_19205) | 4111840..4111998 | + | 159 | WP_004247025.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 62 a.a. Molecular weight: 7049.30 Da Isoelectric Point: 10.9659
>T182027 WP_004247035.1 NZ_CP065039:4106898-4107083 [Proteus mirabilis]
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
MKSSELIKLLEKNGWILDRIKGSHHQFTHPDFSFVVTVPHPRKDLKKGTLNQIIKSAKLKN
Download Length: 186 bp
>T182027 NZ_CP086265:c3310881-3310468 [Ralstonia sp. RS647]
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA
ATGCCCGCGACTGAGGCATTCTTCGACAGCAATGTCGTGCTGTACCTGCTGTCGGCCGACACCGCCAAGGCCGATGCGGC
GGAAACGCTGCTGATGACCGGCGGTGTCGTCAGCGTACAGGTACTGAACGAAACGACGCACGTGATGCGCCGCAAGCTGG
CCATGCCGTGGCACGCGATCGAAACGGTGCAGGAGGCCGTGCGTGCGCAATGCCGGGTCGAGCCGCTGACGCTCGAAACC
CATGATCTCGGACGGCGTATCGCAGAACGCTACGGATTGTCGGTCTATGACGCACTGATCGTCGCGGCGGCATTGCTTGC
CGGCTGCAACGTTCTGTATTCCGAGGATATGCAGCACGGCCTGGTGATCGAGCAGCATCTGCGCATCGTCAATCCTTTTC
CGGCACGGGCATGA
Antitoxin
Download Length: 138 a.a. Molecular weight: 15251.98 Da Isoelectric Point: 4.3830
>AT182027 WP_004247034.1 NZ_CP065039:4107130-4107543 [Proteus mirabilis]
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
MLYPAFIEIDEDGSASGWFPDIDGCIFAGDSIEEAHADARSAIDAHFELLSEKGLDIPSPKSQQEHLINSSGDYNNGIWL
LVDVDMDKYDGRAERINITLPHRLLSRIDTIVKTNPEYGSRSGFIATATRKELQKNI
Download Length: 414 bp
>AT182027 NZ_CP086265:c3311101-3310868 [Ralstonia sp. RS647]
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA
ATGCAAGTCTCGAAATGGGGCAACAGCCTCGCTATCCGGCTGCCGGCGGCCGTTGTGGAGGCGCTTCAGCTGCACGAAGG
CGACGACGTCGAGGTGGTGATCGCGGGCGAGCGCTCGTTTGGCGTCCGCCGCAAGCGCGCTGCGCGCGAGCTTTTCGACC
GGATCCACCAATATCGCGGCAAGCTGCCCGCCGATTTCATCTTCGAGCGCGACCAGGCCAATGCCCGCGACTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|