Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 2196348..2198070 | Replicon | chromosome |
| Accession | NZ_CP065039 | ||
| Organism | Proteus mirabilis strain XH1653 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A0U2S2I2 |
| Locus tag | I1A52_RS10135 | Protein ID | WP_064497040.1 |
| Coordinates | 2197132..2198070 (+) | Length | 313 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | A0A934MVJ4 |
| Locus tag | I1A52_RS10130 | Protein ID | WP_000095577.1 |
| Coordinates | 2196348..2197139 (+) | Length | 264 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| I1A52_RS10100 (I1A52_10090) | 2192021..2192302 | + | 282 | WP_000433889.1 | type IV conjugative transfer system protein TraL | - |
| I1A52_RS10105 (I1A52_10095) | 2192299..2192925 | + | 627 | WP_000667170.1 | TraE/TraK family type IV conjugative transfer system protein | - |
| I1A52_RS10110 (I1A52_10100) | 2192909..2193805 | + | 897 | WP_048608549.1 | type-F conjugative transfer system secretin TraK | - |
| I1A52_RS10115 (I1A52_10105) | 2193808..2195097 | + | 1290 | WP_143475779.1 | TraB/VirB10 family protein | - |
| I1A52_RS10120 (I1A52_10110) | 2195172..2195744 | + | 573 | WP_024008834.1 | type IV conjugative transfer system lipoprotein TraV | - |
| I1A52_RS10125 (I1A52_10115) | 2195741..2196127 | + | 387 | WP_032469918.1 | TraA family conjugative transfer protein | - |
| I1A52_RS10130 (I1A52_10120) | 2196348..2197139 | + | 792 | WP_000095577.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| I1A52_RS10135 (I1A52_10125) | 2197132..2198070 | + | 939 | WP_064497040.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| I1A52_RS10140 (I1A52_10130) | 2198202..2198894 | + | 693 | WP_001228924.1 | DsbC family protein | - |
| I1A52_RS10145 (I1A52_10135) | 2198894..2201293 | + | 2400 | WP_064497039.1 | type IV secretion system protein TraC | - |
| I1A52_RS10150 (I1A52_10140) | 2201286..2201633 | + | 348 | WP_064497038.1 | hypothetical protein | - |
| I1A52_RS10155 (I1A52_10145) | 2201617..2202129 | + | 513 | WP_175215521.1 | S26 family signal peptidase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | erm(42) / floR / aph(6)-Id / aph(3')-VIa / aph(3'')-Ib / sul2 / tet(C) / fosA3 / blaCTX-M-65 / aph(4)-Ia / aac(3)-IVa / aac(6')-Ib-cr / blaOXA-1 / catB3 / ARR-3 / qacE / sul1 / blaNDM-1 / ere(A) / aadA2 / tet(J) | htpB | 2082927..2354313 | 271386 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 313 a.a. Molecular weight: 35542.81 Da Isoelectric Point: 4.9912
>T182025 WP_064497040.1 NZ_CP065039:2197132-2198070 [Proteus mirabilis]
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
MDKDSPYYKQVSLLIRMLPVVATETVFALKGGTAINLFVRDFPRLSVDIDLAYLPLEPRDEALINVRAALQRITDRINTQ
PDIRAAFQDNKADELRIIVSSPVATIKIEVSPVARGTLHSAEIMAVQESVEYEFGYAEIQVVSLPDLYGGKLCAAMDRQH
PRDLFDVRMLLGSEGVSREILVGFLTYTLSHPRPINEVMSPNWQPLNEKFQAEFDGMTFEKVECEDLASVRPMMLTSLQK
HFTERDYAFLMSFKRGQPDWALFDYPNAADLPAIRWKLQNINKLAKNQAKHQEQLDKLKQVLDDWLVNANAE
Download Length: 939 bp
>T182025 NZ_CP086262:5142-5396 [Escherichia coli]
ATGAGAAAAAACAAAGGGCGGTTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
ATGAGAAAAAACAAAGGGCGGTTGACTTATTATCTTGAAGTGATTGATAAAAAATACCATTTTGTAAAAAAAATAAGCAG
TTATTCAAAGGAGTTCACTGACGGAAAAACAAAAAGAACAAAGAGAACGTTAAGTGAGCTGGTTTTTAATGAAAGTGAGG
TCGAGGCAATAGACTTTACAAAAAATGGTTTAAGACCTGTTGATAAGAATATTCTCTTAACTATGGTGAAAGAATATAAG
GAGAGTGATGCATGA
Antitoxin
Download Length: 264 a.a. Molecular weight: 30109.49 Da Isoelectric Point: 9.5097
>AT182025 WP_000095577.1 NZ_CP065039:2196348-2197139 [Proteus mirabilis]
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
MSSKINWLVAHTSPGALVLQQWLTENGVSYSLAQKYAQNGWLKKLSSGVYYRPNAQGDIKPTWVDAIQALDVQLGVPVHL
AGLSSLTHQGLSHYLQLNKEQVWICVKNKSSLPKWFREFPYQNWFYCGNHKLEVNPEKDLKRITVKEKELTVSCAELAAY
EVVDAIGKLISFEHVAELFQGLVNLSPRKVQDILERSSSVQANRIFLFLGRYYDHQWVNRIDETRIKLGAGKRQVVEKGR
FDERYQITVPEILSVKKGEQHNG
Download Length: 792 bp
>AT182025 NZ_CP086262:5393-5635 [Escherichia coli]
ATGACTATCGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
ATGACTATCGAAAATACACCGGAAAACATAAAGAAATTACGTAAAAAAATTGGCCTTACCCAGACAGAGTGCGGTGAGAT
TTTTGGCGTAGGCTTAAGTACATGGCAGAAAAAAGAAGCTAAAACCCACAACCAGCTTAATTTATCGAAAGGTGAATTTG
AGTACCTGTTATTACTTGCAGGGGAGCACCCTGAATACGTCCTGCATAAAAAAGCTGAATCCCGCTCACCGGAGGAACCG
TGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|