Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-MqsA
Location 1817708..1818407 Replicon chromosome
Accession NZ_CP065039
Organism Proteus mirabilis strain XH1653

Toxin (Protein)


Gene name relE Uniprot ID B4EZ96
Locus tag I1A52_RS08420 Protein ID WP_004249093.1
Coordinates 1818021..1818407 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B4EZ97
Locus tag I1A52_RS08415 Protein ID WP_004246828.1
Coordinates 1817708..1818028 (-) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A52_RS08385 (I1A52_08365) 1812836..1813111 - 276 WP_004246820.1 DNA-directed RNA polymerase subunit omega -
I1A52_RS08390 (I1A52_08370) 1813166..1813789 - 624 WP_004246821.1 guanylate kinase -
I1A52_RS08395 (I1A52_08375) 1814091..1814708 - 618 WP_004246822.1 trimeric intracellular cation channel family protein -
I1A52_RS08400 (I1A52_08380) 1814845..1816131 + 1287 WP_049196833.1 DUF3748 domain-containing protein -
I1A52_RS08405 (I1A52_08385) 1816348..1817232 + 885 WP_012368526.1 endonuclease/exonuclease/phosphatase family protein -
I1A52_RS08410 (I1A52_08390) 1817225..1817659 + 435 WP_004246827.1 hypothetical protein -
I1A52_RS08415 (I1A52_08395) 1817708..1818028 - 321 WP_004246828.1 helix-turn-helix domain-containing protein Antitoxin
I1A52_RS08420 (I1A52_08400) 1818021..1818407 - 387 WP_004249093.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
I1A52_RS08425 (I1A52_08405) 1818569..1820641 - 2073 WP_004246830.1 glycine--tRNA ligase subunit beta -
I1A52_RS08430 (I1A52_08410) 1820651..1821556 - 906 WP_004246832.1 glycine--tRNA ligase subunit alpha -
I1A52_RS08435 (I1A52_08415) 1821807..1822388 + 582 WP_004246833.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-125)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-95)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14294.64 Da        Isoelectric Point: 10.0642

>T182024 WP_004249093.1 NZ_CP065039:c1818407-1818021 [Proteus mirabilis]
MVIYKTKMFKNSFKKITLTNAELIAIATEVLAGQFEADLGGGVIKKRACIQGKGKSSGIRTIIFYKQGNNLFFADGWKKS
SLSSKKTKEITDDELESYKDLAKDLFNANQNKIDKMIALGLLTEVKYD

Download         Length: 387 bp

>T182024 NZ_CP086261:c37082-36807 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGTCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
TGCCGCCAGAACGGTACAGTCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAAATTAATGGCCAGACTATTTAT
GTATTGCGTCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12126.21 Da        Isoelectric Point: 10.4411

>AT182024 WP_004246828.1 NZ_CP065039:c1818028-1817708 [Proteus mirabilis]
MTDKMKEMLKFAQEMEDAGVTDGSTTKRIAARIKAKELQAKYKHPTPMTGEDIKRIREQNNISQSSLALILNMTKESVSK
WERNEIKPNGAALRLLHLIDKKILFI

Download         Length: 321 bp

>AT182024 NZ_CP086261:c37366-37082 [Escherichia coli]
ATGCAAATGAAAAACAATGCCGCACAAGCAACAAAAGTAATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGACTGGAACGTTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTTATCGACCATCAGGCTGTACAGGCCTGG
TCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB B4EZ96

Antitoxin

Source ID Structure
AlphaFold DB B4EZ97

References