Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1530650..1532221 Replicon chromosome
Accession NZ_CP065039
Organism Proteus mirabilis strain XH1653

Toxin (Protein)


Gene name hipA Uniprot ID A0A411AN16
Locus tag I1A52_RS07150 Protein ID WP_036895880.1
Coordinates 1530908..1532221 (+) Length 438 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID B4F0T9
Locus tag I1A52_RS07145 Protein ID WP_004249771.1
Coordinates 1530650..1530907 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A52_RS07120 (I1A52_07105) 1526612..1526755 + 144 WP_004246509.1 50S ribosomal protein L34 -
I1A52_RS07125 (I1A52_07110) 1526773..1527132 + 360 WP_004246510.1 ribonuclease P protein component -
I1A52_RS07130 (I1A52_07115) 1527096..1527356 + 261 WP_012368639.1 membrane protein insertion efficiency factor YidD -
I1A52_RS07135 (I1A52_07120) 1527359..1528999 + 1641 WP_004246512.1 membrane protein insertase YidC -
I1A52_RS07140 (I1A52_07125) 1529137..1530501 + 1365 WP_004246513.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
I1A52_RS07145 (I1A52_07130) 1530650..1530907 + 258 WP_004249771.1 helix-turn-helix domain-containing protein Antitoxin
I1A52_RS07150 (I1A52_07135) 1530908..1532221 + 1314 WP_036895880.1 type II toxin-antitoxin system HipA family toxin Toxin
I1A52_RS07155 (I1A52_07140) 1532623..1533087 + 465 WP_004246516.1 DUF1097 domain-containing protein -
I1A52_RS07160 (I1A52_07145) 1533272..1534201 + 930 WP_004246518.1 metallophosphoesterase -
I1A52_RS07165 (I1A52_07150) 1534233..1536194 + 1962 WP_049208705.1 insecticidal delta-endotoxin Cry8Ea1 family protein -
I1A52_RS07170 (I1A52_07155) 1536248..1537051 - 804 WP_004249775.1 energy transducer TonB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 438 a.a.        Molecular weight: 49698.84 Da        Isoelectric Point: 6.5023

>T182022 WP_036895880.1 NZ_CP065039:1530908-1532221 [Proteus mirabilis]
MASLDVYMNEYYVGIFTKKSSGAHSFQYTEDWVNQPGSRPISLSMPLQLQEYQGDCVYNFFDNLLPDNTEIRNRIVSRYN
ANSNQPFDLLAAIGADTVGALRLLPSGSTPADIKKIEYQKLNDIELEKILLGYKSNTPLGMLKEYTDFRISIAGAQEKTA
LLLKDNHWCVPHNNTPTTHIIKLPIGVIESHSYTMDLSNSVENEYLCTLIAKEFDLPVPHCSIIKTKNVKALAVERFDRK
YSSDKSWIIRLPQEDFCQILNIPSALKYENEGGPGIIDIMKYLLGSSNADQDRFHFMKAQVLFWLLAATDGHAKNFSVFI
NQEGRFHLTPLYDIMSIYPNFGGRGLNPRDVKLAMGLKASRGKKYAIEQIFPRHFYQTAEAVGFDPSLMSDILRYFYQEM
DDVIQRVKQQLPEDFPSEISNTILDGMKARAVRLANI

Download         Length: 1314 bp

>T182022 NZ_CP086261:c31034-30729 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTAATCCCCCTGGCCAGTGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAACTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCTGATCTCAGCCACTGGGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9878.43 Da        Isoelectric Point: 10.0139

>AT182022 WP_004249771.1 NZ_CP065039:1530650-1530907 [Proteus mirabilis]
MIIINAYQLSVHLKDVRLTKKLSQSKVAQKVGIRQDTVSNFELNPNSTKLETFFKLLSALNLEMEIHPKDAKNNLAHKSE
WKEEW

Download         Length: 258 bp

>AT182022 NZ_CP086261:c31254-31036 [Escherichia coli]
ATGAAGCAGCGTATTACAGTGACAGTTGACAGCGACAGCTATCAGCTGCTCAAGGCGTATGACGTGAATATCTCCGGTCT
GGTCAGTACGACCATGCAGAACGAAGCCCGGCGACTGCGTGCTGAACGCTGGCAGGCTGAAAATCAGGAAGGGATGGCAG
AGGTCGCCAAGTTTATTGAAATGAACGGCTCTTTTGCCGATGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A411AN16

Antitoxin

Source ID Structure
AlphaFold DB B4F0T9

References