Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 1513494..1514095 Replicon chromosome
Accession NZ_CP065039
Organism Proteus mirabilis strain XH1653

Toxin (Protein)


Gene name doc Uniprot ID A0A2X2BIG8
Locus tag I1A52_RS07070 Protein ID WP_004246497.1
Coordinates 1513712..1514095 (+) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A1Z1SPN9
Locus tag I1A52_RS07065 Protein ID WP_004246496.1
Coordinates 1513494..1513715 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
I1A52_RS07040 (I1A52_07025) 1508574..1509125 + 552 WP_046127252.1 helix-turn-helix domain-containing protein -
I1A52_RS07045 (I1A52_07030) 1509408..1509797 + 390 WP_223232000.1 metal-dependent hydrolase -
I1A52_RS07050 (I1A52_07035) 1509807..1510961 + 1155 WP_046127254.1 SAVED domain-containing protein -
I1A52_RS07055 (I1A52_07040) 1510954..1512144 + 1191 WP_046127255.1 nucleotidyltransferase -
I1A52_RS07060 (I1A52_07045) 1512145..1512846 + 702 WP_046127256.1 hypothetical protein -
I1A52_RS07065 (I1A52_07050) 1513494..1513715 + 222 WP_004246496.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
I1A52_RS07070 (I1A52_07055) 1513712..1514095 + 384 WP_004246497.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
I1A52_RS07075 (I1A52_07060) 1514502..1514816 + 315 WP_004246498.1 helix-turn-helix transcriptional regulator -
I1A52_RS07080 (I1A52_07065) 1515078..1516067 + 990 WP_223232001.1 HipA domain-containing protein -
I1A52_RS07085 (I1A52_07070) 1516424..1517323 - 900 WP_124725698.1 N-acetylmuramic acid 6-phosphate etherase -
I1A52_RS07090 (I1A52_07075) 1517599..1518162 - 564 WP_012368640.1 rRNA adenine N-6-methyltransferase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-115)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 14471.53 Da        Isoelectric Point: 8.5125

>T182021 WP_004246497.1 NZ_CP065039:1513712-1514095 [Proteus mirabilis]
MIWVSAQEVIAFHDRILQRFPGVAGMSDPGRAEALIYRVQNRKHYEGITDVFELAATYWVAIARGHIFNDGNKRTAFFVT
MTFLYRNGIRIRDTGNMLENLTVEAATGEKTVDQLAKHLQNLVEKTN

Download         Length: 384 bp

>T182021 NZ_CP086260:c71590-71315 [Escherichia coli]
ATGGAACTGAAGTGGACCAGTAAGGCGCTTTCTGATTTGGCGCGGTTATATGATTTTCTGGTGCTGGCCAGTAAACCTGC
GGCCGCCAGAACGGTGCAATCCCTGACACAGGCACCGGTCATTCTGTTAACTCATCCACGTATGGGAGAACAGTTGTTTC
AGTTTGAACCCAGGGAGGTCAGACGGATTTTTGCTGGCGAGTACGAAATCCGTTACGAACTTAATGGCCAGACTATTTAT
GTATTGCGCCTGTGGCACACACGAGAAAACAGGTAG

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8260.23 Da        Isoelectric Point: 5.5667

>AT182021 WP_004246496.1 NZ_CP065039:1513494-1513715 [Proteus mirabilis]
MRTYTSTQARANISEVLDIATHGEPVEITRRDGCSAVVISKTEFESYQNAKLDAEFDMMMQRHGHTVEALTNR

Download         Length: 222 bp

>AT182021 NZ_CP086260:c71874-71590 [Escherichia coli]
ATGCAAATGAAAAACAATACCGCACAGGCAACAAAAGTCATTACCGCGCATGTGCCATTACCTATGGCTGATAAAGTCGA
CCAGATGGCCGCCAGGCTGGAACGCTCCCGGGGCTGGGTTATCAAACAGGCGCTTTCTGCATGGCTTGCCCAGGAGGAGG
AGCGTAATCGCCTGACGCTGGAAGCCCTGGACGATGTGACATCCGGACAGGTCATCGACCATCAGGCTGTACAGGCCTGG
GCGGACAGCCTCAGTACTGACAATCCGTTACCGGTGCCACGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X2BIG8

Antitoxin

Source ID Structure
AlphaFold DB A0A1Z1SPN9

References