Detailed information of TA system TA182020

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 775384..776044
• Replicon: chromosome
• Accession: NZ_CP065039
• Organism: Proteus mirabilis strain XH1653

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: I1A52_RS03605
• Protein ID: WP_004245133.1
• Coordinates: 775619..776044 (+)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8E3RLN2
• Locus tag: I1A52_RS03600
• Protein ID: WP_004245128.1
• Coordinates: 775384..775626 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
I1A52_RS03580 (I1A52_03575)	771357..772322	+	966	WP_004245124.1	ribose ABC transporter permease	-
I1A52_RS03585 (I1A52_03580)	772362..773252	+	891	WP_004245125.1	ribose ABC transporter substrate-binding protein RbsB	-
I1A52_RS03590 (I1A52_03585)	773330..774256	+	927	WP_004245126.1	ribokinase	-
I1A52_RS03595 (I1A52_03590)	774261..775268	+	1008	WP_012367471.1	ribose operon transcriptional repressor RbsR	-
I1A52_RS03600 (I1A52_03595)	775384..775626	+	243	WP_004245128.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
I1A52_RS03605 (I1A52_03600)	775619..776044	+	426	WP_004245133.1	type II toxin-antitoxin system VapC family toxin	Toxin
I1A52_RS03610 (I1A52_03605)	776472..776807	+	336	WP_004245134.1	zinc ribbon domain-containing protein YjdM	-
I1A52_RS03615 (I1A52_03610)	776893..777873	-	981	WP_004245135.1	thiamine-phosphate kinase	-
I1A52_RS03620 (I1A52_03615)	777967..778380	-	414	WP_004245136.1	transcription antitermination factor NusB	-
I1A52_RS03625 (I1A52_03620)	778409..778879	-	471	WP_004245137.1	6,7-dimethyl-8-ribityllumazine synthase	-
I1A52_RS03630 (I1A52_03625)	779092..780249	-	1158	WP_004245138.1	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD	-
I1A52_RS03635 (I1A52_03630)	780298..780747	-	450	WP_004245139.1	transcriptional regulator NrdR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-125)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15924.18 Da
• Isoelectric Point: 6.4879

>T182020 WP_004245133.1 NZ_CP065039:775619-776044 [Proteus mirabilis]
MIKYLLDTNIVIFTIKRKPEFLLPKFNQHAEQLAISTITLAELIFGAEKSVNPAKNLATVNDFVSRLTVLSYDDLAAFHY
GDIRATLEKQGKRIGDNDLHIAAHARSKGLIVVTNNTREFERVDGLRIEDWTVINSDPQTD

Nucleotide

• Length: 426 bp

>T182020 NZ_CP086259:c5066904-5066593 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9390.48 Da
• Isoelectric Point: 4.6182

>AT182020 WP_004245128.1 NZ_CP065039:775384-775626 [Proteus mirabilis]
MIQYGKVFMSNRTQNVRLPAETRFPDDVKEVFVRVKGKERIITPIQNAWDSFFLSEKSVTDDFLSERPDQATSERESFDD

Nucleotide

• Length: 243 bp

>AT182020 NZ_CP086259:c5066592-5066302 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTCAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG