Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 94384..94928 Replicon plasmid unnamed1
Accession NZ_CP065038
Organism Leifsonia sp. ZF2019

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IT072_RS21180 Protein ID WP_223361082.1
Coordinates 94650..94928 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A9E6X5J5
Locus tag IT072_RS21175 Protein ID WP_025159513.1
Coordinates 94384..94653 (+) Length 90 a.a.

Genomic Context

IT072_RS21150IT072_RS21175IT072_RS21180IT072_RS21185IT072_RS21200IT072_RS21205IT072_RS21145IT072_RS21155IT072_RS21160IT072_RS21165IT072_RS21170IT072_RS21190IT072_RS21195IT072_RS21210
Location: 90875..91039 (165 bp)
Type: Others
Protein ID: WP_223361078.1
Location: 94384..94653 (270 bp)
Type: Antitoxin
Protein ID: WP_025159513.1
Location: 94650..94928 (279 bp)
Type: Toxin
Protein ID: WP_223361082.1
Location: 94973..95287 (315 bp)
Type: Others
Protein ID: WP_223361083.1
Location: 96786..97710 (925 bp)
Type: Others
Protein ID: Protein_99
Location: 97829..98827 (999 bp)
Type: Others
Protein ID: Protein_100
Location: 90415..90654 (240 bp)
Type: Others
Protein ID: WP_223361077.1
Location: 91079..91285 (207 bp)
Type: Others
Protein ID: WP_223361079.1
Location: 91332..91874 (543 bp)
Type: Others
Protein ID: WP_223361080.1
Location: 91977..93108 (1132 bp)
Type: Others
Protein ID: Protein_92
Location: 93514..94077 (564 bp)
Type: Others
Protein ID: WP_223361081.1
Location: 95644..96150 (507 bp)
Type: Others
Protein ID: WP_223361084.1
Location: 96286..96474 (189 bp)
Type: Others
Protein ID: WP_223361085.1
Location: 98961..99845 (885 bp)
Type: Others
Protein ID: WP_223361086.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT072_RS21145 (IT072_21030)90415..90654-240WP_223361077.1hypothetical protein-
IT072_RS21150 (IT072_21035)90875..91039+165WP_223361078.1hypothetical protein-
IT072_RS21155 (IT072_21040)91079..91285-207WP_223361079.1hypothetical protein-
IT072_RS21160 (IT072_21045)91332..91874-543WP_223361080.1hypothetical protein-
IT072_RS21165 (IT072_21050)91977..93108-1132Protein_92IS30 family transposase-
IT072_RS21170 (IT072_21060)93514..94077-564WP_223361081.1hypothetical protein-
IT072_RS21175 (IT072_21065)94384..94653+270WP_025159513.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IT072_RS21180 (IT072_21070)94650..94928+279WP_223361082.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT072_RS21185 (IT072_21075)94973..95287+315WP_223361083.1hypothetical protein-
IT072_RS21190 (IT072_21080)95644..96150-507WP_223361084.1hypothetical protein-
IT072_RS21195 (IT072_21085)96286..96474-189WP_223361085.1hypothetical protein-
IT072_RS21200 (IT072_21090)96786..97710+925Protein_99IS5 family transposase-
IT072_RS21205 (IT072_21095)97829..98827+999Protein_100IS481 family transposase-
IT072_RS21210 (IT072_21100)98961..99845-885WP_223361086.1hypothetical protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid--1..101776101776
-insideIScluster/Tn--91977..986776700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(13-89)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-71)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10385.08 Da        Isoelectric Point: 10.5026

>T182019 WP_223361082.1 NZ_CP065038:94650-94928 [Leifsonia sp. ZF2019]
VKDPSYRIELSRPAARALARLTPKMADAVLRFLDGPLSDNPMRVTKPLGAELQGMRSGYVGIAYRVLVRVDEEQRLVEVM
RIAHRSDAYRGF

Download         Length: 279 bp

>T182019 NZ_CP086259:c4788612-4788439 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9582.68 Da        Isoelectric Point: 4.1413

>AT182019 WP_025159513.1 NZ_CP065038:94384-94653 [Leifsonia sp. ZF2019]
MQTMSVSEAKDKLSNLVEGVEATHDAVVITRHGKPAAVLISPEDLDALQETLAWLSDPSHAAEMAEAEEDAAEGRMLSLD
EVRAQLANR

Download         Length: 270 bp

>AT182019 NZ_CP086259:c4788936-4788640 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References