Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 1437101..1437642 Replicon chromosome
Accession NZ_CP065037
Organism Leifsonia sp. ZF2019

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag IT072_RS07065 Protein ID WP_223360246.1
Coordinates 1437376..1437642 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag IT072_RS07060 Protein ID WP_223360245.1
Coordinates 1437101..1437379 (+) Length 93 a.a.

Genomic Context

IT072_RS07035IT072_RS07040IT072_RS07045IT072_RS07050IT072_RS07055IT072_RS07060IT072_RS07065IT072_RS07075IT072_RS07080IT072_RS07090IT072_RS07070IT072_RS07085IT072_RS07095
Location: 1432758..1433441 (684 bp)
Type: Others
Protein ID: WP_223360240.1
Location: 1433434..1434879 (1446 bp)
Type: Others
Protein ID: WP_223360241.1
Location: 1434904..1435512 (609 bp)
Type: Others
Protein ID: WP_223360242.1
Location: 1435573..1436244 (672 bp)
Type: Others
Protein ID: WP_223360243.1
Location: 1436241..1437050 (810 bp)
Type: Others
Protein ID: WP_223360244.1
Location: 1437101..1437379 (279 bp)
Type: Antitoxin
Protein ID: WP_223360245.1
Location: 1437376..1437642 (267 bp)
Type: Toxin
Protein ID: WP_223360246.1
Location: 1438708..1439322 (615 bp)
Type: Others
Protein ID: WP_223360248.1
Location: 1439334..1440125 (792 bp)
Type: Others
Protein ID: WP_223360249.1
Location: 1440565..1441017 (453 bp)
Type: Others
Protein ID: WP_223360251.1
Location: 1437677..1438642 (966 bp)
Type: Others
Protein ID: WP_223360247.1
Location: 1440133..1440501 (369 bp)
Type: Others
Protein ID: WP_223360250.1
Location: 1441062..1442453 (1392 bp)
Type: Others
Protein ID: WP_223360252.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
IT072_RS07035 (IT072_07000)1432758..1433441+684WP_223360240.1response regulator transcription factor-
IT072_RS07040 (IT072_07005)1433434..1434879+1446WP_223360241.1HAMP domain-containing sensor histidine kinase-
IT072_RS07045 (IT072_07010)1434904..1435512+609WP_223360242.1DUF5666 domain-containing protein-
IT072_RS07050 (IT072_07015)1435573..1436244+672WP_223360243.1FCD domain-containing protein-
IT072_RS07055 (IT072_07020)1436241..1437050+810WP_223360244.1ATP-binding cassette domain-containing protein-
IT072_RS07060 (IT072_07025)1437101..1437379+279WP_223360245.1type II toxin-antitoxin system Phd/YefM family antitoxinAntitoxin
IT072_RS07065 (IT072_07030)1437376..1437642+267WP_223360246.1type II toxin-antitoxin system RelE/ParE family toxinToxin
IT072_RS07070 (IT072_07035)1437677..1438642-966WP_223360247.1NAD(P)/FAD-dependent oxidoreductase-
IT072_RS07075 (IT072_07040)1438708..1439322+615WP_223360248.1XRE family transcriptional regulator-
IT072_RS07080 (IT072_07045)1439334..1440125+792WP_223360249.1alpha/beta fold hydrolase-
IT072_RS07085 (IT072_07050)1440133..1440501-369WP_223360250.1VOC family protein-
IT072_RS07090 (IT072_07055)1440565..1441017+453WP_223360251.1MarR family transcriptional regulator-
IT072_RS07095 (IT072_07060)1441062..1442453-1392WP_223360252.1DUF2252 domain-containing protein-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-85)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-73)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10241.81 Da        Isoelectric Point: 9.8737

>T182015 WP_223360246.1 NZ_CP065037:1437376-1437642 [Leifsonia sp. ZF2019]
MTYEVIFASTAVRDLERIPPRIVPAVIEFAYGDLARNPRRVGKALERELSGLFSARRGPYRILYEIQDEEVRVLVVRVDH
RADAYRPR

Download         Length: 267 bp

>T182015 NZ_CP086259:4097331-4097609 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGAGGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10123.37 Da        Isoelectric Point: 4.5686

>AT182015 WP_223360245.1 NZ_CP065037:1437101-1437379 [Leifsonia sp. ZF2019]
MQTLPISAVKARLSELVDSASHTREEVAITVNGSPAAMLIGIDEWEELQERLHWLSTGDDLVARLAEARREVESGGGLGE
DEIRARFGVPRR

Download         Length: 279 bp

>AT182015 NZ_CP086259:4097068-4097328 [Escherichia coli]
ATGGCTGCTAACGCATTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCGGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCGTTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References