182011

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2875280..2875907 Replicon chromosome
Accession NZ_CP065036
Organism Pectobacterium parmentieri strain PB20

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag PB20LOC_RS13135 Protein ID WP_005976087.1
Coordinates 2875704..2875907 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C6DB73
Locus tag PB20LOC_RS13130 Protein ID WP_005976089.1
Coordinates 2875280..2875648 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PB20LOC_RS13115 2870751..2873879 + 3129 WP_015730969.1 multidrug efflux RND transporter permease subunit -
PB20LOC_RS13120 2874112..2874360 + 249 WP_015730970.1 type B 50S ribosomal protein L31 -
PB20LOC_RS13125 2874378..2874521 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
PB20LOC_RS13130 2875280..2875648 + 369 WP_005976089.1 Hha toxicity modulator TomB Antitoxin
PB20LOC_RS13135 2875704..2875907 + 204 WP_005976087.1 hemolysin expression modulator Hha Toxin
PB20LOC_RS13145 2876635..2876955 + 321 WP_005976085.1 MGMT family protein -
PB20LOC_RS13150 2876975..2877559 - 585 WP_015730971.1 YbaY family lipoprotein -
PB20LOC_RS13155 2877770..2878633 + 864 WP_014700820.1 acyl-CoA thioesterase II -
PB20LOC_RS13160 2878751..2880037 - 1287 WP_014700821.1 ammonium transporter AmtB -
PB20LOC_RS13165 2880077..2880415 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T182011 WP_005976087.1 NZ_CP065036:2875704-2875907 [Pectobacterium parmentieri]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T182011 NZ_CP086259:c2929980-2929877 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14032.77 Da        Isoelectric Point: 4.4787

>AT182011 WP_005976089.1 NZ_CP065036:2875280-2875648 [Pectobacterium parmentieri]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENVCTPAKT

Download         Length: 369 bp

>AT182011 NZ_CP086259:2929839-2930110 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A1D7Z3G5

References