Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 443477..444137 Replicon chromosome
Accession NZ_CP065036
Organism Pectobacterium parmentieri strain PB20

Toxin (Protein)


Gene name cptA Uniprot ID A0A8B3EZX7
Locus tag PB20LOC_RS02130 Protein ID WP_012822581.1
Coordinates 443724..444137 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A0H3I0G9
Locus tag PB20LOC_RS02125 Protein ID WP_012822580.1
Coordinates 443477..443743 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PB20LOC_RS02105 439469..440473 - 1005 WP_103807861.1 substrate-binding domain-containing protein -
PB20LOC_RS02110 440527..441135 - 609 WP_014698756.1 HD domain-containing protein -
PB20LOC_RS02115 441546..442193 + 648 WP_012822578.1 hemolysin III family protein -
PB20LOC_RS02120 442248..443249 - 1002 WP_012822579.1 tRNA-modifying protein YgfZ -
PB20LOC_RS02125 443477..443743 + 267 WP_012822580.1 FAD assembly factor SdhE Antitoxin
PB20LOC_RS02130 443724..444137 + 414 WP_012822581.1 protein YgfX Toxin
PB20LOC_RS02135 444363..445298 + 936 WP_012822582.1 23S rRNA (adenine(1618)-N(6))-methyltransferase RlmF -
PB20LOC_RS02140 445386..445709 - 324 WP_012822583.1 hypothetical protein -
PB20LOC_RS02145 445738..446256 - 519 WP_012822584.1 flavodoxin FldB -
PB20LOC_RS02150 446584..447600 + 1017 WP_012822585.1 methionine ABC transporter ATP-binding protein -
PB20LOC_RS02155 447593..448261 + 669 WP_012822586.1 ABC transporter permease -
PB20LOC_RS02160 448279..449097 + 819 WP_033071942.1 MetQ/NlpA family ABC transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-132)

Antitoxin

Flavinator of succinate dehydrogenase

(8-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16259.20 Da        Isoelectric Point: 10.7923

>T182009 WP_012822581.1 NZ_CP065036:443724-444137 [Pectobacterium parmentieri]
VAQWQCDLRVSWRMQLLSLVVHGLLVLLILLAPWPDGYAWLWLCLVTMVMFGFIRSQRNIKSRQGCITLLSETTLNWRQQ
EWRIVKRPWLLKNGVLLALQSANGKDKQQLWLASDSMGDDEWRHLRQLLLQQKHWAR

Download         Length: 414 bp

>T182009 NZ_CP086259:c2170422-2170315 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10519.99 Da        Isoelectric Point: 5.1392

>AT182009 WP_012822580.1 NZ_CP065036:443477-443743 [Pectobacterium parmentieri]
MEIDNKSRIHWACRRGMRELDIAIMPFFEHDYDTLNDIDKRTFVRLLQSDDPDLFNWLMNHGEPEDGELKRMISLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT182009 NZ_CP086259:2170469-2170535 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A8B3EZX7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3I0G9

References