Detailed information of TA system TA182003

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 4701762..4703443
• Replicon: chromosome
• Accession: NZ_CP065034
• Organism: Klebsiella pneumoniae strain 2016-1400

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: GOY40_RS22975
• Protein ID: WP_087787586.1
• Coordinates: 4701762..4702679 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: GOY40_RS22980
• Protein ID: WP_087787585.1
• Coordinates: 4702685..4703443 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GOY40_RS22955	4697068..4698588	+	1521	WP_004210021.1	sugar ABC transporter ATP-binding protein	-
GOY40_RS22960	4698585..4699583	+	999	WP_002885172.1	ribose ABC transporter permease	-
GOY40_RS22965	4699614..4700555	+	942	WP_087787587.1	ABC transporter substrate-binding protein	-
GOY40_RS22970	4700630..4701637	+	1008	WP_004178300.1	carbohydrate kinase family protein	-
GOY40_RS22975	4701762..4702679	-	918	WP_087787586.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
GOY40_RS22980	4702685..4703443	-	759	WP_087787585.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
GOY40_RS22985	4703529..4704257	-	729	WP_002885152.1	response regulator transcription factor	-
GOY40_RS22990	4704530..4706677	+	2148	WP_087787584.1	formate dehydrogenase subunit alpha	-
GOY40_RS22995	4706907..4707593	+	687	WP_004151733.1	sel1 repeat family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (95-246)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34697.17 Da
• Isoelectric Point: 5.4707

>T182003 WP_087787586.1 NZ_CP065034:c4702679-4701762 [Klebsiella pneumoniae]
IDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIVALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

>T182003 NZ_CP086259:1472769-1473167 [Escherichia coli]
ATGCTGAAATTCATGCTGGATACCAATATCTGTATTTTCACTATTAAGAATAAACCAGTACATGTCAGAGAGCGGTTTAA
CCTGAATTCTGGCCGGATGTGTATAAGTTCTGTAACATTGATGGAGCTTATCTATGGGGCAGAAAAAAGTCAGATGCCAG
AACGCAATTTGGCGGTGATTGAAGGTTTCGTATCTCGTTTGGAAGTGCTTGATTATGATAGTGCTGCTGCGACGCATACC
GGGCAAATCAGGGCCGAGCTTGCCCGGCAGGGAAGGCCTGTTGGACCTTTTGACCAGATGATAGCGGGACATGCTCGCAG
TCGCGGTTTGATTGTGGTTACCAACAATACCCGAGAGTTTGAGCGAGTGGCGGGAATCAGACTAGAAGATTGGAGCTAA

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28576.98 Da
• Isoelectric Point: 10.0870

>AT182003 WP_087787585.1 NZ_CP065034:c4703443-4702685 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYVRAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp

>AT182003 NZ_CP086259:1472542-1472769 [Escherichia coli]
ATGGAAACTACTGTATTTTTAAGTAATCGCAGTCAGGCCGTCAGATTACCGAAAGCGGTCGCTCTGCCAGAGGATGTTAA
GAAAGTAGAAATTATTGCGATTGGTCGTACAAGAATCATCACTCCCGCCGGTGAGTCCTGGGACAGTTGGTTTGATGGCG
AAAATGTGAGTGCGGATTTTATGGATATCCGTGATCAACCCGCAATGCAGGAAAGGGAATCATTCTGA