Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3848964..3849583 Replicon chromosome
Accession NZ_CP065034
Organism Klebsiella pneumoniae strain 2016-1400

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag GOY40_RS18875 Protein ID WP_002892050.1
Coordinates 3849365..3849583 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag GOY40_RS18870 Protein ID WP_002892066.1
Coordinates 3848964..3849338 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOY40_RS18860 3844116..3845309 + 1194 WP_087787916.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
GOY40_RS18865 3845332..3848478 + 3147 WP_002892069.1 multidrug efflux RND transporter permease subunit AcrB -
GOY40_RS18870 3848964..3849338 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
GOY40_RS18875 3849365..3849583 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
GOY40_RS18880 3849742..3850308 + 567 WP_002892030.1 maltose O-acetyltransferase -
GOY40_RS18885 3850280..3850420 - 141 WP_004147370.1 hypothetical protein -
GOY40_RS18890 3850441..3850911 + 471 WP_002892026.1 YlaC family protein -
GOY40_RS18895 3850886..3852337 - 1452 WP_087787915.1 PLP-dependent aminotransferase family protein -
GOY40_RS18900 3852438..3853136 + 699 WP_002892021.1 GNAT family N-acetyltransferase -
GOY40_RS18905 3853133..3853273 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
GOY40_RS18910 3853273..3853536 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T182000 WP_002892050.1 NZ_CP065034:3849365-3849583 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T182000 NZ_CP086259:c867568-867191 [Escherichia coli]
ATGAATACATTACCCGACACTCACGTACGGGAGGCATCGGGCTGCCCGTCTCCCATCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTCACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGCGCTGGTACGTACCGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCACGCCGGGCAACCGGCCTGATGACACGCGA
CAACTACAGAACGGTAAATAACATTACCCTGGGTAAACATCCGGGGGCGAAACAATGA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT182000 WP_002892066.1 NZ_CP065034:3848964-3849338 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT182000 NZ_CP086259:c867992-867615 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCCTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCCCGACTGGTACAGGAGGGTAACCGCCTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCAGGT
TCAGCGACGTAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACTGGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACACTGTATGCGAAAGGGCTGACCTGCGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCGGCAGCGCCCGCAACCACCGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References