Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 794113..794770 Replicon chromosome
Accession NZ_CP065034
Organism Klebsiella pneumoniae strain 2016-1400

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag GOY40_RS03980 Protein ID WP_002916310.1
Coordinates 794360..794770 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag GOY40_RS03975 Protein ID WP_002916312.1
Coordinates 794113..794379 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOY40_RS03950 789269..790702 - 1434 WP_087787962.1 6-phospho-beta-glucosidase BglA -
GOY40_RS03955 790821..791549 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
GOY40_RS03960 791599..791910 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
GOY40_RS03965 792074..792733 + 660 WP_002916317.1 hemolysin III family protein -
GOY40_RS03970 792884..793867 - 984 WP_087787963.1 tRNA-modifying protein YgfZ -
GOY40_RS03975 794113..794379 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
GOY40_RS03980 794360..794770 + 411 WP_002916310.1 protein YgfX Toxin
GOY40_RS03985 794777..795298 - 522 WP_002916308.1 flavodoxin FldB -
GOY40_RS03990 795399..796295 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
GOY40_RS03995 796318..797031 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
GOY40_RS04000 797037..798770 + 1734 WP_193579921.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T181989 WP_002916310.1 NZ_CP065034:794360-794770 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T181989 NZ_CP086254:193529-193819 [Brachybacterium halotolerans subsp. kimchii]
ATGAAACGCTTCCGCCTCACTCCGGCAGCGCAGAGGGATCTCTCCGAGATCTGGGACTTCACGGAAGACCGCTGGAGCGC
CTCGCAGGCGGAGTCCTACCTGCGCGACATCCAGAACGCCATCGAGCGCCTCGCCGCAGACCCGGATCGGGGTCGCCCCG
TCGACGACATCCGCCAGGGCTACCGTCGATACGGGATCGGCAGCCACCTCGTCTTCTACGTCCAGCGCGGAGATCGCATC
GACGTGATCCGTATCCTCCACCAGCGGATGGATCCGGGGCGGCATCTGTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT181989 WP_002916312.1 NZ_CP065034:794113-794379 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT181989 NZ_CP086254:193299-193532 [Brachybacterium halotolerans subsp. kimchii]
ATGGCTCAGAACACGTCGATCAGCCTTGATGACCACTACTCCGGCTTCCTTGCAGAGCAGGTCGCCTCGGGTCGCTATCG
ATCGTCCAGCGAGGTGATCCGTGCCGGGCTGCGCCTCCTCGAGGATCGGGAGACGCAACTGGCAGCACTGCGCGAGGCCC
TCGTCGTCGGCGAGGAGAGCGGTGAGGCCCAGCCGTTCGACTTCGACGCCTTCATCGCGTCGAAGCAGGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References