Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ykfI-yfjZ/CbtA-CbeA
Location 660642..661324 Replicon chromosome
Accession NZ_CP065034
Organism Klebsiella pneumoniae strain 2016-1400

Toxin (Protein)


Gene name ykfI Uniprot ID -
Locus tag GOY40_RS03290 Protein ID WP_047666954.1
Coordinates 660983..661324 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name yfjZ Uniprot ID -
Locus tag GOY40_RS03285 Protein ID WP_047666955.1
Coordinates 660642..660962 (+) Length 107 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
GOY40_RS03240 655995..656699 + 705 WP_047666967.1 WYL domain-containing protein -
GOY40_RS03245 656699..657268 + 570 WP_047666965.1 hypothetical protein -
GOY40_RS03250 657305..657757 + 453 WP_015699705.1 hypothetical protein -
GOY40_RS03255 657754..658203 + 450 WP_169546675.1 hypothetical protein -
GOY40_RS03260 658275..658505 + 231 WP_047666960.1 DUF905 domain-containing protein -
GOY40_RS03265 658604..659425 + 822 WP_047666958.1 DUF945 domain-containing protein -
GOY40_RS03270 659456..659899 + 444 WP_047666957.1 antirestriction protein -
GOY40_RS03275 659908..660390 + 483 WP_047666956.1 RadC family protein -
GOY40_RS03280 660399..660620 + 222 WP_016151535.1 DUF987 domain-containing protein -
GOY40_RS03285 660642..660962 + 321 WP_047666955.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
GOY40_RS03290 660983..661324 + 342 WP_047666954.1 TA system toxin CbtA family protein Toxin
GOY40_RS03300 661686..662192 + 507 WP_002917636.1 G/U mismatch-specific DNA glycosylase -
GOY40_RS03305 662292..664133 - 1842 WP_004174339.1 RNA polymerase sigma factor RpoD -
GOY40_RS03310 664352..666097 - 1746 WP_004149864.1 DNA primase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 646663..661324 14661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-105)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12888.95 Da        Isoelectric Point: 9.6542

>T181988 WP_047666954.1 NZ_CP065034:660983-661324 [Klebsiella pneumoniae]
MKTLPATISRAAKPCLSPVAVWQMLLTRLLEQHYGLTLNDTPFSDETVIKEHIDAGITLADAVNFLVDKYELVRIDRRGF
NWQEQSPYLRAVDILRARQAIGLLRRSRNNAVL

Download         Length: 342 bp

>T181988 NZ_CP086253:4458405-4459724 [Pectobacterium aquaticum]
ATGGCTGCGCTCGATGTTTACATGAACGGCTATCGGGTGGGGATTCTGACCAAAACGGGCAGTGGGGCACATCATTTTTC
CTATGATGCGAACTGGCTCGGGTTGCCGGGGAGTCGCCCCATTTCGCTTTCTATGCCGCTACGTCATCAGCCCTATCAAG
GTGATGAGGTTTATAATTTCTTCGACAATTTGTTGCCGGATAACCCGGATATCAGAAGACGCATTGTCGCCAGACATCAC
GCTGACTCCACCCAGCCGTTTGATCTGCTGGCTAAAGTGGGGCAAGACAGTGTCGGGGCGTTGCAATTAGTGCCGCAGGG
TACACCTGTGCACGATATAAAAAAGATCAAATACAAAACTTTATCTGAGCAGCAGCTTGAAAACATACTGGCGGGATACC
TGTCCGATGCCCCGCTGGGGATGATTGATACAGAAGACAATTTTCGTATCTCTATCGCGGGCGCACAGGAAAAGACGGCG
CTGCTTTATCTGGATGATCACTGGTGCCTGCCTCTCAATGCCACACCAACTACCCACATCATCAAGCTACCGATTGGTAA
AATCGAGAGTCACTCTTACTCAATTGATATGTCTGACAGCGTTGAAAATGAGTATCTGTGCCTGCTCATTGCCAAGGCAT
TTGGGTTGCCAGTGCCGCACTGTTTTATGATCAACGCTGGCAAGATAAAGGCGTTGGCGGTGGAGCGTTTTGATCGTAAA
TACGCCTCGGATGTCAGTTGGATTATGCGGTTACCACAAGAGGATTTTTGTCAGGTATTAAACGTTCCTTCCGCACTGAA
ATATGAAAATCATGGTGGACCGGGTATTTCCGCCATTATGTCGTTTCTATTGGGTTCGGCTGATCCAGAAAGGGATCGTT
ATCGCTTTATGCAGGCTCAGGTACTGTTTTGGCTATTGGCTGCAACGGATGGTCATGCGAAAAATTTTTCCCTGTTTATT
GAATCTGAGGGACGATATCGACTCACGCCTTTCTATGACATTCTCTCTATGTATCCGGCGATGGGCGGACGGGGAATTGA
CCACAGAGAGGCCAAATTGGCGATGGGATTGACTGGCTCAAGAGGCAAGAAATATGCGATTGAGCAGATCTTTCCCCGGC
ATTTTTTCCAGACGGCGAAGGCCGTTGGGTTTGCCAGAGAATCGATGGAAAACATTCTGGTGGAGTTTTCAAACACCGTT
GAGACCGTTATGACGACTGTTGGAAGTCAACTGCCTGTGGATTTTCCTACTCATATCAGTGATGCAATCCTGACCGGGTT
GCAGGCTAGATCGAGACGGCTCATGAGAGGATGGGAGTAA

Antitoxin


Download         Length: 107 a.a.        Molecular weight: 12049.53 Da        Isoelectric Point: 6.6255

>AT181988 WP_047666955.1 NZ_CP065034:660642-660962 [Klebsiella pneumoniae]
MSSNVTWGLQRDNTPRLGARLVQEGNRLHYLADRASITGKLSDAECRRLDETFPHFISQMESMLTTDELNPRHAHCVTLY
HNGFTCEAETLGSCGYVYIAIYPTQR

Download         Length: 321 bp

>AT181988 NZ_CP086253:4458139-4458405 [Pectobacterium aquaticum]
ATGAAGGTCACCAACAGCAAGCAGCTTAGCAGCTACCTGAAAGATGTTCGTATCACGCAGAAGCTTTCACAAGGGAAAGT
GGCCAGTAAAGTGGGTATTCGCCAGGATACGGTATCCAGCTTCGAGCAACATCCTGATTCCACCAAGCTGGAAACCTTCT
TTAAAATCCTGTCGGCATTGAACTTAGAACTTACTGTTACGCCCCGAAATGTGAATACCGCCAATAACGAAGCCTCTGTT
GCATCATCCTGGAAGGAAGAATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References