Detailed information of TA system TA181984

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 4107977..4108449
• Replicon: chromosome
• Accession: NZ_CP065032
• Organism: Serratia sp. CMO1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5C7D428
• Locus tag: IT763_RS19575
• Protein ID: WP_049208401.1
• Coordinates: 4107977..4108252 (-)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IT763_RS19580
• Protein ID: WP_206194943.1
• Coordinates: 4108258..4108449 (-)
• Length: 64 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IT763_RS19550	4103296..4104576	-	1281	WP_028127378.1	polysaccharide deacetylase family protein	-
IT763_RS19555	4104754..4105524	-	771	WP_004937535.1	ABC transporter permease	-
IT763_RS19560	4105521..4106444	-	924	WP_015379030.1	ABC transporter ATP-binding protein	-
IT763_RS19565	4106655..4107311	+	657	WP_016930066.1	carbonate dehydratase	-
IT763_RS19570	4107350..4107886	-	537	WP_004937527.1	hypoxanthine phosphoribosyltransferase	-
IT763_RS19575	4107977..4108252	-	276	WP_049208401.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IT763_RS19580	4108258..4108449	-	192	WP_206194943.1	stability determinant	Antitoxin
IT763_RS19585	4108555..4110198	-	1644	WP_164053471.1	multicopper oxidase CueO	-
IT763_RS19590	4110415..4110762	+	348	WP_033634347.1	YacC family pilotin-like protein	-
IT763_RS19595	4110888..4111751	+	864	WP_016930071.1	polyamine aminopropyltransferase	-
IT763_RS19600	4111779..4112573	+	795	WP_004937510.1	adenosylmethionine decarboxylase	-
IT763_RS19605	4112606..4112968	-	363	WP_016930072.1	protein YacL	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10410.13 Da
• Isoelectric Point: 6.8785

>T181984 WP_049208401.1 NZ_CP065032:c4108252-4107977 [Serratia sp. CMO1]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
VSVLHARQEYP

Nucleotide

• Length: 276 bp

>T181984 NZ_CP086253:c3419360-3418785 [Pectobacterium aquaticum]
ATGAATCACTCCCCCTATCCCGTGGTACTTGATGCGTGTGTCATTTATCCATCCTTGCTACGAGATTTGCTCATGCATCT
TGGTTTAACAGGGCTATATCAGCCAAAGTGGACGGTAAAAATTCAGGAAGAGTGGCAGCGAAATTTGTTGCTAAATAACG
CTGACGTAACGATGGATAAGCTCAGGAACATTGAGCATCTGATGAATAAGGCATTACCTGATGCCAATGTGACTGGATAC
GAGCAACTTATCTCTGCTCTGGTTTTACCTGATGTGGGTGATCGACATGTATTGGCAGCGGCGATACGCGCTAATGCAGA
AGTCATCGTCACTGCGAATCTGAAAGACTTTCCAGCAACGGCACTTTTCGAATTTGGAGTGGAAGCCATGCATCCAGACG
ACTTCATTGCCGATTTATTTGATCTCAATTCTGCTCTGGTGCTTAAAGCGGTTCGCACTTCGCGCACTGCCTTCAGAAAG
CCTCCGTTTGATGTGGACGAGTATCTGGATTGTCTCCAGCGTCAGGGACTACCAATGACGGTAAAAGAACTGGATGCGTA
TCGATCACTGATTTAA

Antitoxin

Protein

• Length: 64 a.a.
• Molecular weight: 7248.05 Da
• Isoelectric Point: 6.4623

>AT181984 WP_206194943.1 NZ_CP065032:c4108449-4108258 [Serratia sp. CMO1]
MPTKLDPIVSEFETQEQADSYDRWFRRTVESSINSDSSRIPHDEVMAGARHIIEQAKAKRKSA

Nucleotide

• Length: 192 bp

>AT181984 NZ_CP086253:c3419821-3419360 [Pectobacterium aquaticum]
ATGAAAAATACTCCTCTAAATAGTTTGAGCCTTCCGGCTCCAAAAGAAATGGAGGCCGCTATCCGTGGACAAAGGCAGCT
TGCAACCTACCTGTCTACGAAGCTGGAAACACAGGAAATTTCGATTCAGGATGCGCATGATATTGCCCATCGGATCGAGT
TGCCTACCTCAGCACTCACGCTTTTGATGAGTATCCTTGGCGAACTGGCGGCGGGTAATGCTGTCCAGATTGTCCCCGTG
CAGGCTGAGTTAACGACACAAGAAGCGGCAAATATTCTGAATGTTTCACGGCCACATATGGTGAAGCTTTTGGAAGAAGG
CCATCTTCCTTTCCATAAAACAGGTCGTCATCGCCGCGTGCTTTTTGCTGATTTGATGCAATACAAAGAACAGCGTGAAA
ATGAAAGTATGCAAGCCATGCAGGAGCTGACAGACCGAAGTCAGGAACTCGGGTTTTACTAA

Structures

Toxin

• AlphaFold DB: A0A5C7D428